2,3-difluoro-N-[4-[1-[2-(fluoromethyl)tetrazol-5-yl]-4-methyl-3,6-dihydro-2H-pyridin-5-yl]phenyl]benzamide | 1375464-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-difluoro-N-[4-[1-[2-(fluoromethyl)tetrazol-5-yl]-4-methyl-3,6-dihydro-2H-pyridin-5-yl]phenyl]benzamide
• CAS: 1375464-28-0
• 化学式: C₂₁H₁₉F₃N₆O
• 分子量: 428.417
• InChiKey: ZGTQELIPOCQKNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  75.9
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• TETRAZOLYL-TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
  申请人：Bohnert Gary

  公开号：US20130289071A1

  公开（公告）日：2013-10-31

  The invention relates to certain compounds according to formula (I): or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

  该发明涉及按式(I)表示的某些化合物：或其药学上可接受的盐、溶剂合物、包合物或前药，其作为免疫抑制剂和用于治疗和预防炎症疾病、过敏性疾病和免疫性疾病具有用途。
• [EN] TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES<br/>[FR] COMPOSÉS DE TÉTRAZOLYL-TÉTRAHYDROPYRIDINE POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET IMMUNITAIRES
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2012064808A1

  公开（公告）日：2012-05-18

  The invention relates to certain compounds according to formula (I): or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.