6-(2-chlorophenyl)-7-(4-trifluoromethylphenyl)-2-(2-hydroxyethoxy)-3-[N-(3-methyl-1,1-dioxotetrahydrothien-3-yl)carbamoyl]pyrazolo[1,5-a]pyrimidine | 1001424-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2-chlorophenyl)-7-(4-trifluoromethylphenyl)-2-(2-hydroxyethoxy)-3-[N-(3-methyl-1,1-dioxotetrahydrothien-3-yl)carbamoyl]pyrazolo[1,5-a]pyrimidine
• 英文别名: 6-(2-chlorophenyl)-2-(2-hydroxyethoxy)-N-(3-methyl-1,1-dioxothiolan-3-yl)-7-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
• CAS: 1001424-35-6
• 化学式: C₂₇H₂₄ClF₃N₄O₅S
• 分子量: 609.026
• InChiKey: VMVACHAXDHXBRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST
  申请人：Tanimoto Koichi

  公开号：US20090258867A1

  公开（公告）日：2009-10-15

  The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R 1 and R 2 are the same or different and each an optionally substituted aryl group etc, R 0 is hydrogen atom, an alkyl group etc, E is a group of the formula: —C(═O)— or —SO 2 —, R is a group of the following formula [i], [ii] or [iii] etc: Ring A is (a) a C 3-8 cycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, R 3 is an alkyl group optionally substituted by an alkylthio group, R 4 is hydrogen atom, an alkyl group etc, one of R A and R B is an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有CB1受体拮抗活性的吡唑并[1,5-a]嘧啶化合物，其化学式[I]如下：其中，R1和R2相同或不同，分别是可选取代的芳基等；R0是氢原子，烷基等；E是以下式子的基团：—C(═O)—或—SO2—；R是以下式子[i]、[ii]或[iii]等的基团：环A是(a)一个C3-8环烷基，可选地融合到苯环上，或(b)一个苯环；Q是单键或亚甲基基团；环B是一个4-7个成员的脂肪族杂环基团，该环基团通过其环碳原子与相邻的氮原子结合；X是硫原子等；R3是可选取代的烷基，可以是烷基硫基等；R4是氢原子，烷基等；RA和RB中的一个是烷基等，另一个是氢原子，烷基等，或其药学上可接受的盐。
• Pyrazolo[1,5-a]pyrimidine compounds as CB1 receptor antagonists
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2520577A1

  公开（公告）日：2012-11-07

  The present invention provides pyrazolo[1,5-a]pyrimidine compounds and pharmaceutically acceptable salts thereof having CB1 receptor-antagonizing activity. These compounds, and compositions comprising the same, are hence useful in the treatment of a wide range of conditions and diseases.

  本发明提供了具有 CB1 受体拮抗活性的吡唑并[1,5-a]嘧啶化合物及其药学上可接受的盐类。这些化合物及其组合物可用于治疗多种病症和疾病。
• PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2035427B1

  公开（公告）日：2013-12-11
• US8163759B2
  申请人：——

  公开号：US8163759B2

  公开（公告）日：2012-04-24
• US8921380B2
  申请人：——

  公开号：US8921380B2

  公开（公告）日：2014-12-30