8-[1,5-Bis(4-chlorophenyl)pyrazol-3-yl]-1,4-dioxaspiro[4.5]decan-8-ol | 1224949-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-[1,5-Bis(4-chlorophenyl)pyrazol-3-yl]-1,4-dioxaspiro[4.5]decan-8-ol
• CAS: 1224949-59-0
• 化学式: C₂₃H₂₂Cl₂N₂O₃
• 分子量: 445.345
• InChiKey: BDWVFGLBGRUVMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Morita Yasuhiro

  公开号：US20120270906A1

  公开（公告）日：2012-10-25

  A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.

  一种缓解伤害性疼痛和神经病理性疼痛并具有较少副作用的方法。该化合物包括以下化合物所代表的环己烷衍生物，或其药学上可接受的盐或前药。
• THERAPEUTIC AGENT AND PREVENTATIVE AGENT FOR ALZHEIMER'S DISEASE
  申请人：Toray Industries, Inc.

  公开号：EP2565184B1

  公开（公告）日：2015-12-30
• THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR URINE COLLECTION DISORDER
  申请人：Hareyama Nana

  公开号：US20130041157A1

  公开（公告）日：2013-02-14

  A therapeutic agent or prophylactic agent is effective for therapy of urine storage disorders, by which agent improvement of side effects due to an anticholinergic action is attained as well as which agent also has an analgesic effect. The agent includes as an effective ingredient a cyclohexane derivative exemplified by the formula below, a pharmaceutically acceptable salt thereof, or a prodrug thereof.
• THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR FIBROMYALGIA
  申请人：Yoshida Chihiro

  公开号：US20130190503A1

  公开（公告）日：2013-07-25

  A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective ingredient a cyclohexane derivative or a pharmaceutically acceptable salt thereof or a prodrug thereof.
• US8247569B2
  申请人：——

  公开号：US8247569B2

  公开（公告）日：2012-08-21