benzoic acid,(1R,2R)-2-iodocyclohexan-1-ol | 54826-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoic acid,(1R,2R)-2-iodocyclohexan-1-ol
• 英文别名: trans-2-iodocyclohexyl benzoate；(+/-)-trans-2-iodo-1-benzoyloxy-cyclohexane；(+/-)-trans-2-Jod-1-benzoyloxy-cyclohexan；Benzoesaeure-2-iod-cyclohexylester；trans-2-Iod-cyclohexylbenzoat；trans-Iodcyclohexylbenzoat
• CAS: 54826-40-3；100714-24-7
• 化学式: C₁₃H₁₅IO₂
• 分子量: 330.165
• InChiKey: RWRNAIAWYOCRDI-RYUDHWBXSA-N

物化性质

• 沸点：
  135-137 °C(Press: 0.2 Torr)
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  benzoic acid,(1R,2R)-2-iodocyclohexan-1-ol 、 silver benzoate 、 苯 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  OBESITY : A MODERN DAY PLAGUE

  摘要：

  Obesity is the presence of excess body fat. Unfortunately obesity is taken as a mere cosmetic problem and not a medical one. Today obesity is being 'dealt' with more by the self-proclaimed fitness experts running the rapidly mushrooming fitness centres rather than by medical professionals. But rather than merely a cosmetic problem, obesity should be viewed as a disease because there are multiple biologic hazards at surprisingly low levels of excess fat With the rapid pace of industrialisation and economic progress, today more and more jobs are becoming sedentary and dietary patterns are also changing with a decline in the cereal intake and increase in the intake of sugar and fats. However, inherited physiologic differences in response to eating and exercise are also important factors. Treating obesity can often be a frustrating experience for both the physician and the patient because of the great difficulty in maintaining weight loss over the long term. However, a clear understanding of the causes of obesity and a treatment strategy based on a combination of diet, nutrition, education, exercise, behaviour modification and social support can go a long way in containing this 'modern day plague' before it acquires epidemic proportions.

  DOI：

  10.1016/s0377-1237(02)80016-8
• 作为产物：
  描述：

  silver benzoate 在 四氯化碳 、 碘 作用下， 生成 benzoic acid,(1R,2R)-2-iodocyclohexan-1-ol
  参考文献：
  名称：

  Uschakow; Tschistow; Schlossberg, Zhurnal Obshchei Khimii, 1935, vol. 5, p. 1397

  摘要：

  DOI：

文献信息

• Reactions of thallium(I) carboxylates and iodine with alkenes
  作者：Richard C. Cambie、Rodney C. Hayward、John L. Roberts、Peter S. Rutledge

  DOI：10.1039/p19740001858

  日期：——

  Treatment of an alkene with a thallium(I) carboxylate and iodine gives the corresponding vic-iodocarboxylate in high yield. The reactions are regiospecific and in conjunction with solvolysis of the products, offer an alternative to the Prévost reaction. Differences in the behaviour of thallium(I) carboxylates and silver carboxylates towards alkenes in the presence of iodine are discussed.

  用铊（烯烃的治疗我）羧酸酯和碘给出了相应的VIC以高收率-iodocarboxylate。该反应是区域特异性的，并与产物的溶剂分解结合，提供了Prévost反应的替代方法。讨论了在碘存在下of （I）羧酸盐和羧酸银对烯烃的行为差异。
• Thallium(<scp>I</scp>) carboxylates: a new class of reagents for the formation of α-iodocarboxylates
  作者：Richard C. Cambie、Rodney C. Hayward、John L. Roberts、Peter S. Rutledge

  DOI：10.1039/c39730000359

  日期：——

  Treatment of an alkene with a thallium(I) carboxylate and iodine gives the corresponding α-iodocarboxylate in high yield, thereby affording a regiospecific and inexpensive modification for the Prevost reaction.

  用羧酸（（I）和碘处理烯烃可得到高产率的相应α-碘代羧酸盐，从而为Prevost反应提供了区域特异性和廉价的修饰。
• THE REACTION OF ORGANOHALIDES WITH NICKEL CARBONYL IN THE PRESENCE OF OLEFIN OXIDES
  作者：Ilsong Rhee、Membo Ryang、Hideo Hasegawa、Shinji Murai、Noboru Sonoda

  DOI：10.1246/cl.1978.15

  日期：1978.1.5

  Reaction of aroyl- or alkenoylnickel carbonyl halide complexes, derived from the reaction of organohalides with nickel carbonyl, with olefin oxides afforded halohydrin esters.

  芳酰基-或链烯酰基镍羰基卤化物配合物，衍生自有机卤化物与羰基镍的反应，与烯烃氧化物反应得到卤代醇酯。
• Visible Light-Assisted Ring-Opening of Cyclic Ethers with Carboxylic Acids Mediated by Triphenylphosphine and <i>N</i>-Halosuccinimides
  作者：Dhiraj K. Jha、Sandhya Acharya、Nagaraju Sakkani、Samantha Chapa、Andrew Guerra、John C.-G. Zhao

  DOI：10.1021/acs.orglett.3c03805

  日期：2024.1.12

  (epoxide, oxetane, THF, and THP) by carboxylic acids was achieved by using N-iodosuccinimide (NIS) or N-bromosuccinimide (NBS) and triphenylphosphine under blue light. The corresponding ω-haloalkyl carboxylates were obtained under mild reaction conditions. The reaction is believed to work through a halogen bond complex between NIS (or NBS) and triphenylphosphine, which, upon irradiation with blue light

  在蓝光下使用N-碘代琥珀酰亚胺(NIS)或N-溴代琥珀酰亚胺(NBS)和三苯基膦实现了羧酸对环醚(环氧化物、氧杂环丁烷、THF和THP)的开环。在温和的反应条件下得到相应的ω-卤代烷基羧酸盐。该反应被认为是通过NIS（或NBS）和三苯基膦之间的卤素键络合物进行的，在蓝光照射下，该络合物产生关键的膦自由基阳离子中间体，引发开环反应。
• Barluenga, Jose; Martinez-Gallo, Jose M.; Najera, Carmen, Journal of Chemical Research, Miniprint, 1986, # 8, p. 2416 - 2443
  作者：Barluenga, Jose、Martinez-Gallo, Jose M.、Najera, Carmen、Yus, Miguel

  DOI：——

  日期：——