3,3-diphenylbenzo[c]thiophene-1(3H)-thione | 55548-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-diphenylbenzo[c]thiophene-1(3H)-thione
• 英文别名: 3,3-diphenyl-3H-benzo[c]thiophene-1-thione；3,3-Diphenyl-3H-benzo[c]thiophen-1-thion；3,3-Diphenyldithiophthalide；3,3-diphenyl-2-benzothiophene-1-thione
• CAS: 55548-99-7
• 化学式: C₂₀H₁₄S₂
• mdl: MFCD00223053
• 分子量: 318.463
• InChiKey: WTFAKQKABURDBN-UHFFFAOYSA-N

物化性质

• 沸点：
  454.1±55.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,3-diphenylbenzo[c]thiophene-1(3H)-thione 在 高氯酸 、 三氟化硼乙醚 作用下， 以 氯仿 为溶剂， 反应 0.92h， 生成 3,3-diphenyl-1-<4-(3,5-diphenyl-2-pyrazolin-1-yl)phenyl>thiophthalylium perchlorate
  参考文献：
  名称：

  Oparin, D. A.; Gella, I. M.; Maskevich, S. A., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 3.2, p. 445 - 449

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯酞內酯 在 tetraphosphorus decasulfide 作用下， 以 xylene 为溶剂， 反应 18.0h， 以99%的产率得到3,3-diphenylbenzo[c]thiophene-1(3H)-thione
  参考文献：
  名称：

  A Precipitator for the Detection of Thiophilic Metals in Aqua

  摘要：

  The detection of toxic metals including mercury and lead has become a vital analytical tool for environmental remediation and regulation of food stocks. A prevalent obstacle with the current assessment of metal ion contamination originates from the lack of adequate assay throughput. In this context, a critical concern with current analyses stems from the fact that the majority of these assays are solution-based, and thus the response is highly dependent upon the assay environment. Herein, we describe a fluorescent dye-doped crystalline assay that offers convincing metal selection and provides detection comparable to conventional solution-based ligands used for the spectrofluorometric analysis of thiophilic heavy metal ions. While comparable in analytical performance to known methodologies, the formation of crystalline analytes provides for signal amplification and, consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems. This procedure has been tested in a variety of scenarios and shows good performance using readily available equipment, including a commercially available Universal Serial Bus (USB) CCD camera. Furthermore, when developed in a microcapillary format, this assay is capable of screening thousands of samples per day for the presence of subnanomolar concentrations of Hg2+ using a conventional fluorescence microscope.

  DOI：

  10.1021/ja045798r

文献信息

• Subnanomolar Precipitator of Thiophilic Metals
  申请人：Janda Kim D.

  公开号：US20080241943A1

  公开（公告）日：2008-10-02

  A fluorescent dye-doped crystalline assay is employed for selection and detection of thiophilic heavy metal ions. While comparable in analytical performance to known solution based methodologies, the formation of crystalline analytes provides for signal amplification, and consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems. In a microcapillary format, this assay is capable of screening hundreds of samples per day for the presence of subnanomolar concentrations of Hg 2+ using a conventional fluorescence microscope.

  采用荧光染料掺杂结晶测定法选择和检测亲硫重金属离子。这种方法与已知的溶液基方法在分析性能上相当，但结晶分析物的形成提供了信号放大，因此，这是一个强大的平台，其分析可直接适用于高通量视频捕获系统。在微型毛细管格式下，该测定法能够使用传统荧光显微镜每天筛选数百个样品，以检测亚纳摩尔浓度的Hg2+的存在。
• Meyer,R.; Szanecki, Chemische Berichte, 1900, vol. 33, p. 2579
  作者：Meyer,R.、Szanecki

  DOI：——

  日期：——
• Labeish; Oparin; Bel'skii, Russian Journal of Organic Chemistry, 1997, vol. 33, # 3, p. 381 - 387
  作者：Labeish、Oparin、Bel'skii、Galishev

  DOI：——

  日期：——
• Oparin, D. A.; Motovilin, D. B.; Galishev, V. A., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 5.2, p. 861
  作者：Oparin, D. A.、Motovilin, D. B.、Galishev, V. A.

  DOI：——

  日期：——
• Oparin, D. A., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 196 - 197
  作者：Oparin, D. A.

  DOI：——

  日期：——