(R)-N-(1-cyanopyrrolidin-3-yl)benzenesulfonamide | 1257876-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-(1-cyanopyrrolidin-3-yl)benzenesulfonamide
• 英文别名: N-[(3R)-1-cyanopyrrolidin-3-yl]benzenesulfonamide
• CAS: 1257876-06-4
• 化学式: C₁₁H₁₃N₃O₂S
• 分子量: 251.309
• InChiKey: FXILBKWGQQHVJE-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  81.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cathepsin C Inhibitors
  申请人：DENG Jianghe

  公开号：US20090264499A1

  公开（公告）日：2009-10-22

  A compound of formula (IA) or (IB) and their use in treating inflammatory diseases such as COPD.

  化合物的公式（IA）或（IB）及其在治疗炎症性疾病如COPD中的用途。
• SULFONAMIDE-SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS
  申请人：MISSION THERAPEUTICS LIMITED

  公开号：US20200172518A1

  公开（公告）日：2020-06-04

  The present invention relates to a class of sulfonamide-substituted cyanopyrrolidines of Formula (Ia) and (Ib) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase L1 (UCHL1) and ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction: (Formulae (Ia), (Ib)).