4'-cyano-6-methylbiphenyl-3-carboxylic acid [6-((R)-2-methylmorpholin-4-yl)pyridin-3-yl]amide | 956698-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-cyano-6-methylbiphenyl-3-carboxylic acid [6-((R)-2-methylmorpholin-4-yl)pyridin-3-yl]amide
• 英文别名: 3-(4-cyanophenyl)-4-methyl-N-[6-[(2R)-2-methylmorpholin-4-yl]pyridin-3-yl]benzamide
• CAS: 956698-15-0
• 化学式: C₂₅H₂₄N₄O₂
• 分子量: 412.491
• InChiKey: ZSUPWEIFBCOKSB-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  78.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BIPHENYLCARBOXAMIDE DERIVATIVES AS HEDGEHOD PATHWAY MODULATORS
  申请人：Dierks Christine

  公开号：US20100197659A1

  公开（公告）日：2010-08-05

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  该发明提供了一种调节刺猬信号通路活性的方法。具体来说，该发明提供了一种抑制由于Ptc功能丧失、刺猬功能增强、smoothened功能增强或Gli功能增强等表型引起的异常生长状态的方法，包括将细胞与化合物I式的足够量接触。
• COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
  申请人：Gao Wenqi

  公开号：US20090203666A1

  公开（公告）日：2009-08-13

  The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

  本发明提供了一种调节刺猬信号通路活性的方法。具体而言，本发明提供了一种通过接触细胞与化合物I的足够量来抑制由于Ptc功能缺失、刺猬功能增强、平滑蛋白功能增强或Gli功能增强等表型引起的异常生长状态的方法。
• US8178563B2
  申请人：——

  公开号：US8178563B2

  公开（公告）日：2012-05-15
• US8507471B2
  申请人：——

  公开号：US8507471B2

  公开（公告）日：2013-08-13
• [EN] COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS<br/>[FR] COMPOSÉS ET COMPOSITIONS MODULANT LE MÉCANISME D'ACTION DE LA HEDGEHOG
  申请人：IRM LLC

  公开号：WO2007131201A2

  公开（公告）日：2007-11-15

  [EN] The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
  [FR] L'invention porte sur une méthode modulant le mécanisme de signalisation de la hedgehog, et en particulier sur une méthode d'inhibition les états aberrants de croissance résultant de phénotypes tels que: la perte de fonction du Ptc, le gain de fonction de la hedgehog, le gain de fonction du Smo, ou le gain de fonction du Gli. Ladite méthode consiste à mettre en contact une cellule avec une quantité suffisante du composé de formule I.