2-chloro-3,5-bis(trichloromethyl)pyridine | 74900-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-3,5-bis(trichloromethyl)pyridine
• CAS: 74900-18-8
• 化学式: C₇H₂Cl₇N
• 分子量: 348.271
• InChiKey: XXRSRYDXYWIFHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chloro-3,5-bis(trichloromethyl)pyridine 生成 2-氯-3,5-二(三氟甲基)吡啶
  参考文献：
  名称：

  JOHNSTON, H.;TROXELL, L. H.

  摘要：

  DOI：

文献信息

• Abnormal nucleophilic substitution of 3-trichloromethylpyridines by methoxide
  作者：Ronald S. Dainter、Hans Suschitzky、Basil J. Wakefield、Nigel Hughes、Anthony J. Nelson

  DOI：10.1016/s0040-4039(01)91414-5

  日期：1984.1

  3-Trichloromethylpyridine and its α-chlorinated derivatives behave as ambident electrophilic substrates towards methoxide which attacks an α-position and the trichloromethyl group.

  3-三氯甲基吡啶及其α-氯代衍生物对攻击α-位和三氯甲基的甲醇盐起着亲电子底物的作用。
• Production of polychlorinated pyridine mixtures by liquid phase
  申请人：Kalama Chemical, Inc.

  公开号：US04507486A1

  公开（公告）日：1985-03-26

  Preparation of high yields of mixtures rich in polychlorinated pyridines by maintaining a chlorine to 3,5-lutidine weight ratio of greater than about 7:1 when reacting chlorine and 3,5-lutidine or 3,5-lutidine hydrochloride non-catalytically in the liquid phase at temperatures in excess of about 150.degree. C., the reactants being contained in a well mixed diluent producing 2 moles or less of hydrogen chlorine per mole of diluent by reaction with the chlorine in the indicated temperature range. Reaction in a primary reactor is followed by selective further chlorination to obtain desired final products useful as intermediates in the formation of herbicides and the like.

  通过在液相中以大于约7:1的氯与3,5-芘啶或3,5-芘啶盐酸盐的重量比反应氯和3,5-芘啶或3,5-芘啶盐酸盐，保持氯与3,5-芘啶重量比大于约7:1，以高于约150°C的温度反应，使用混合稀释剂将反应物混合均匀，每摩尔稀释剂产生不超过2摩尔氢氯酸，随后在初级反应器中进行选择性进一步氯化，以获得所需的最终产物，可用作除草剂等形成中间体。
• Removal of ferric chloride from halopyridines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0228643A2

  公开（公告）日：1987-07-15

  Ferric chloride is removed from mixtures with chlorinated and/or fluorinated pyridines and methyl­pyridines by extraction with diol solvents. For example, the ferric chloride in halopyridine mixtures containing 2,3,5,6-tetrachloropyridine was removed by extraction with ethylene glycol. The purified halopyridines are useful intermediates for the production of insecticides, herbicides, and fungicides.

  用二元醇溶剂萃取可从含氯和/或含氟吡啶和甲基吡啶的混合物中去除氯化铁。 例如，用乙二醇萃取可去除含 2,3,5,6-四氯吡啶的卤代吡啶混合物中的氯化铁。 纯化的卤代吡啶是生产杀虫剂、除草剂和杀真菌剂的有用中间体。
• Dainter, Ronald S.; Jackson, Tracey; Omar, Abdirahman H. H., Journal of the Chemical Society. Perkin transactions I, 1989, # 2, p. 283 - 287
  作者：Dainter, Ronald S.、Jackson, Tracey、Omar, Abdirahman H. H.、Suschitzky, Hans、Wakefield, Basil J.、Hughes, Nigel、Nelson, Anthony J.、Varvounis, George

  DOI：——

  日期：——
• DAINTER R. S.;SUSCHITZKY H.;WAKEFIELD B. J.;HUGHES N.;NELSON A. J., TETRAHEDRON LETT., 1984, 25, N 49, 5693-5696
  作者：DAINTER R. S.、SUSCHITZKY H.、WAKEFIELD B. J.、HUGHES N.、NELSON A. J.

  DOI：——

  日期：——