6α-azidomethyl-6β,14β-epoxy-3-methoxymorphinan | 1130020-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6α-azidomethyl-6β,14β-epoxy-3-methoxymorphinan
• CAS: 1130020-70-0
• 化学式: C₁₈H₂₂N₄O₂
• 分子量: 326.398
• InChiKey: MPWDENNYGSCDKG-BRSBDYLESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  79.25
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  6α-azidomethyl-6β,14β-epoxy-3-methoxymorphinan 在 吡啶 、 palladium on carbon 、 camphor-10-sulfonic acid 、 氢气 、 sodium acetate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 3.08h， 生成 N-[(6β,14β-epoxy-3-methoxy-17-methylmorphinan-6α-yl)methyl]benzamide
  参考文献：
  名称：

  Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies

  摘要：

  A novel 6,14-epoxymorphinan benzamide derivative (NS22) that was previously reported showed opioid kappa receptor agonistic activity and analgesic activity. The unsatisfactory kappa selectivity of NS22 led us to synthesize its derivatives to improve the opioid kappa receptor selectivity and the agonist activity. In the course of SAR of the various derivatives, 17-benzyl-6,14-epoxymorphinan derivatives (KNT-33, 53, 55, 80, 90, 133) were found to show high selectivities and affinities for the opioid kappa receptor. In addition, KNT-33, 53, 55 showed dose-dependent analgesic effects in acetic acid writhing tests. Therefore, 17-benzyl substituents may play an important role for developing kappa selectivity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.035
• 作为产物：
  描述：

  (4bR,6R,8aS,9R)-6-(azidomethyl)-11-(cyclopropylmethyl)-3-methoxy-5,6,7,8,9,10-hexahydro-9,4b-(epiminoethano)-6,8a-epoxyphenanthrene 在 1-氯乙基氯甲酸酯 、 甲醇 作用下， 以 1,1,2,2-四氯乙烷 为溶剂， 反应 4.5h， 以60%的产率得到6α-azidomethyl-6β,14β-epoxy-3-methoxymorphinan
  参考文献：
  名称：

  Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies

  摘要：

  A novel 6,14-epoxymorphinan benzamide derivative (NS22) that was previously reported showed opioid kappa receptor agonistic activity and analgesic activity. The unsatisfactory kappa selectivity of NS22 led us to synthesize its derivatives to improve the opioid kappa receptor selectivity and the agonist activity. In the course of SAR of the various derivatives, 17-benzyl-6,14-epoxymorphinan derivatives (KNT-33, 53, 55, 80, 90, 133) were found to show high selectivities and affinities for the opioid kappa receptor. In addition, KNT-33, 53, 55 showed dose-dependent analgesic effects in acetic acid writhing tests. Therefore, 17-benzyl substituents may play an important role for developing kappa selectivity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.035