Benzoic acid, 3-amino-2-fluoro-5-hydroxy- | 1025127-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid, 3-amino-2-fluoro-5-hydroxy-
• 英文别名: 3-amino-2-fluoro-5-hydroxybenzoic acid
• CAS: 1025127-39-2
• 化学式: C₇H₆FNO₃
• 分子量: 171.13
• InChiKey: JUBGQPYIKIVBSG-UHFFFAOYSA-N

物化性质

• 沸点：
  439.3±45.0 °C(Predicted)
• 密度：
  1.601±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION
  申请人：Bristol-Myers Squibb Company

  公开号：EP1973883B1

  公开（公告）日：2012-07-11
• Novel Compounds and Methods for Their Production
  申请人：Martin Christine

  公开号：US20110021481A1

  公开（公告）日：2011-01-27

  The present invention relates to ansamycin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine.
• 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
  申请人：Martin Christine

  公开号：US20110160175A1

  公开（公告）日：2011-06-30

  The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds involving incorporation of non-natural starter units and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
• US8492370B2
  申请人：——

  公开号：US8492370B2

  公开（公告）日：2013-07-23
• [EN] NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION<br/>[FR] NOUVEAUX COMPOSÉS ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：BIOTICA TECH LTD

  公开号：WO2008056188A2

  公开（公告）日：2008-05-15

  [EN] The present invention relates to ansamycin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine.
  [FR] La présente invention concerne des analogues d'ansamycine trouvant une utilité, par exemple, dans le traitement du cancer, de tumeurs malignes des lymphocytes B, de la malaria, d'une infection fongique, de maladies du système nerveux central et de maladies neurodégénératives, de maladies dépendant de l'angiogenèse ou de maladies auto-immunes, ou dans le traitement préventif du cancer. La présente invention concerne également des procédés de production de ces composés ainsi que leur utilisation en médecine.