(2S,3S,4S,5S,6R)-2-[[1-[2-[2-[2-[2-[4-[9,9-bis[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-2-yl]-2,1,3-benzothiadiazol-7-yl]-9-[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-9-yl]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 1255920-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (2S,3S,4S,5S,6R)-2-[[1-[2-[2-[2-[2-[4-[9,9-bis[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-2-yl]-2,1,3-benzothiadiazol-7-yl]-9-[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-9-yl]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1255920-35-4
• 化学式: C₉₂H₁₂₀N₁₄O₃₂S
• 分子量: 1966.11
• InChiKey: UEVXNBDZWHEXON-MOIMXSPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  139
• 可旋转键数：
  54
• 环数：
  16.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  648
• 氢给体数：
  16
• 氢受体数：
  43

反应信息

• 作为产物：
  描述：

  在 甲醇 、 sodium methylate 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以87%的产率得到(2S,3S,4S,5S,6R)-2-[[1-[2-[2-[2-[2-[4-[9,9-bis[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-2-yl]-2,1,3-benzothiadiazol-7-yl]-9-[2-[2-[2-[4-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]triazol-1-yl]ethoxy]ethoxy]ethyl]fluoren-9-yl]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  Mannose-Substituted Conjugated Polyelectrolyte and Oligomer as an Intelligent Energy Transfer Pair for Label-Free Visual Detection of Concanavalin A

  摘要：

  Mannose-substituted blue-fluorescent cationic conjugated polyelectrolyte (131) and yellow-fluorescent neutral conjugated oligomer (6) are synthesized via the combination of Suzuki coupling polymerization and click chemistry. The spectral overlap between the emission of P1 and the absorption of 6 allows one to blend them to form an intelligent fluorescence resonance energy transfer (FRET) pair for multicolor protein sensing. Despite the nonspecific-interaction-induced perturbation in the polymer emission, strong specific binding between mannose and Concanavalin A (ConA) is able to result in protein-selective FRET from PI to 6. The fluorescence of 6/P1 blend in the presence of ConA is dominated by yellow emission, while it remains blue in the presence of other six nonspecific proteins. The 6/P1 blend thus serves as a multicolor bicomponent FRET probe for label-free visual detection of ConA in a high-contrast and convenient manner. In addition, its linear ratiometric fluorescence response toward ConA enables effective protein quantification with a low limit of detection of similar to 1.5 nM. This study demonstrates the importance of molecular engineering in conjugated polyelectrolyte based label-free chemical and biological sensing.

  DOI：

  10.1021/ma1021264