<3,3'-Bipyridin>-2,2'-diol | 97033-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: <3,3'-Bipyridin>-2,2'-diol
• 英文别名: 3-(2-oxo-1H-pyridin-3-yl)-1H-pyridin-2-one
• CAS: 97033-24-4
• 化学式: C₁₀H₈N₂O₂
• 分子量: 188.186
• InChiKey: FPJAOWVARUHXKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2'-Dimethoxy-3,3'-bipyridine 在 吡啶盐酸盐 作用下， 反应 4.0h， 以84%的产率得到<3,3'-Bipyridin>-2,2'-diol
  参考文献：
  名称：

  Dehmlow, Eckehard V.; Sleegers, Arthur, Liebigs Annalen der Chemie, 1992, # 9, p. 953 - 960

  摘要：

  DOI：

文献信息

• Method of treating cancer
  申请人：——

  公开号：US20030220241A1

  公开（公告）日：2003-11-27

  The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种PSA共轭物和一种前脂蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向所述哺乳动物施用来自以下组中选择的至少两种治疗剂的量，所述组包括一种PSA共轭物和一种前脂蛋白转移酶抑制剂，所述治疗剂可以顺序给药或同时给药。该发明还涉及制备这种组合物的方法。
• Pyridazine and Pyrrole Compounds, Processes For Obtaining Them and Uses
  申请人：Dubreuil Didier Max

  公开号：US20100298562A1

  公开（公告）日：2010-11-25

  The present invention relates to nonlinear oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to oligopyrroles and to the uses of the pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the uses in the materials, environmental, electronics and optics field.

  本发明涉及非线性寡吡啶化合物，以及获得它们的方法，它们的用途，以及将它们还原为寡吡咯和所获得的吡啶基吡咯和寡吡咯化合物的用途。该发明特别涉及用作药物的用途，特别是用于治疗癌症、细菌感染或寄生虫感染等病理的用途，以及在材料、环境、电子和光学领域的用途。
• [EN] A METHOD OF TREATING ENDOMETRIOSIS<br/>[FR] PROCEDE POUR TRAITER L'ENDOMETRIOSE
  申请人：MERCK & CO INC

  公开号：WO2000025789A1

  公开（公告）日：2000-05-11

  A method of preventing and treating endometriosis, uterine fibroids, dysfunctional uterine bleeding and endometrial hyperplasia is disclosed which is comprised of administering to a mammalian patient in need of such treatment an effective amount of a prenyl-protein transferase inhibitor.

  本发明揭示了一种预防和治疗子宫内膜异位症、子宫肌瘤、功能性子宫出血和子宫内膜增生的方法，包括向需要此类治疗的哺乳动物患者投予有效量的戊二酰基-蛋白转移酶抑制剂。
• Azabicyclo [3.1.0] Hexane Derivatives as Modulators of Dopamine D3 Receptors
  申请人：Bertani Barbara

  公开号：US20100063097A1

  公开（公告）日：2010-03-11

  The present invention relates to certain azabicyclic compounds of formula (I)′: wherein the several groups are defined herein and are modulators of dopamine D 3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

  本发明涉及公式（I）'的某些氮杂双环化合物：其中各个基团在此处被定义，并且是多巴胺D3受体调节剂，例如用于治疗药物依赖，作为抗精神病药物，用于治疗强迫症谱系障碍或早泄。
• SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS
  申请人：CONFLUENCE LIFE SCIENCES INC.

  公开号：US20140171450A1

  公开（公告）日：2014-06-19

  The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.

  本公开提供了在治疗p38激酶介导的疾病，如淋巴瘤和自身免疫性疾病中有用的吡啶酮-吡啶基化合物，其结构式为公式（I）所示：其中R1、R2、R3、R4、R5、X和Y如详细说明中所定义；包括至少一个化合物的制药组合物；以及使用该化合物治疗p38激酶介导的疾病的方法。