2-Et-4-t-Bu-1,3-dioxolan | 133279-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 2-Et-4-t-Bu-1,3-dioxolan
• 英文别名: 2,4-Diethyl-1,3-dioxolane
• CAS: 133279-48-8
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: SRDZKBMYGAYNLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：BARYZA Jeremy Lee

  公开号：US20160106842A1

  公开（公告）日：2016-04-21

  This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 -R 4 , L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

  这项发明提供了式(I)的化合物或其药学上可接受的盐，其中R1-R4，L和X的定义如下。式(I)的化合物及其药学上可接受的盐是阳离子脂质，可用于将生物活性剂递送到细胞和组织中。
• Method for production of 1,3-dioxolanes
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0413558A2

  公开（公告）日：1991-02-20

  A method for the production of a 1,3-dioxolane represented by the general formula III: wherein R¹ is hydrogen atom or an alkyl group of 1 to 5 carbon atoms and R² is hydrogen atom or an alkyl group of 1 to 2 carbon atoms or a phenyl group, which method comprises reacting an aldehyde represented by the general formula I wherein R¹ has the same meaning as defined above, with an alkylene oxide represented by the general formula II: wherein R² has the same meaning as defined above, in an alkylene glycol solvent corresponding to said alkylene oxide in the presence of at least one catalyst selected from the group consisting of bromides of alkali metals, iodides of alkali metals, bromides of alkaline earth metals, and iodides of alkaline earth metals.

  一种生产通式 III 所代表的 1，3-二氧戊环的方法： 其中 R¹ 为氢原子或 1 至 5 个碳原子的烷基，R² 为氢原子或 1 至 2 个碳原子的烷基或苯基，该方法包括使通式 I 所代表的醛与通式 II 所代表的环氧亚烷基进行反应 其中 R¹ 的含义与上述定义相同，与通式 II 所代表的氧化亚烷反应： 其中 R² 的含义与上文所定义的相同，在至少一种选自碱金属溴化物、碱金属碘化物、碱土金属溴化物和碱土金属碘化物的催化剂存在下，在与所述环氧亚烷基相对应的烷二醇溶剂中进行反应。
• Laulimalide Analogues as Therapeutic Agents
  申请人：Wender Paul A.

  公开号：US20080280973A1

  公开（公告）日：2008-11-13

  Laulimalide analogues useful as microtubule stabilizing agents, and in the treatment of abnormal cell proliferation, are disclosed. Methods of making the compounds, as well as methods of using such compounds in treating abnormal cell proliferation diseases are also described.
• NOVEL LAULIMALIDE ANALOGUES AS THERAPEUTIC AGENTS
  申请人：WENDER PAUL A.

  公开号：US20090099252A1

  公开（公告）日：2009-04-16

  Laulimalide analogues useful as microtubule stabilizing agents, and in the treatment of abnormal cell proliferation, are disclosed. Methods of making the compounds, as well as methods of using such compounds in treating abnormal cell proliferation diseases are also described.
• THIADIAZOLE COMPOUND AND USE THEREOF
  申请人：Takyo Hayato

  公开号：US20100081693A1

  公开（公告）日：2010-04-01

  A thiadiazole compound represented by the formula (I): wherein R is a hydrogen atom, an optionally substituted C1-C7 chain hydrocarbon group etc., Z is an oxygen atom or a sulfur atom, X is a —NR 2 R 3 group etc., R 2 and R 3 each independently are a hydrogen atom, a C1-C4 alkyl group, a C3-C4 alkenyl group, a C1-C4 alkoxy group, or a phenyl group, or R 2 and R 3 bind to each other at the ends thereof to form a C2-C7 alkanediyl group, has excellent controlling effect on a noxious arthropod.