5-hydroxymethyl-2-(4-chlorophenyl)pyrimidine | 1102229-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-hydroxymethyl-2-(4-chlorophenyl)pyrimidine
• 英文别名: [2-(4-Chlorophenyl)pyrimidin-5-yl]methanol
• CAS: 1102229-82-2
• 化学式: C₁₁H₉ClN₂O
• 分子量: 220.658
• InChiKey: HHGHFYIMQNLWIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
  申请人：——

  公开号：US20020019383A1

  公开（公告）日：2002-02-14

  The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula: 1 in which R 1 represents a radical —NHCOR 4 or —N(R 5 )—Y—R 6 , Y is CO or SO 2 , R 4 represents a radical -alk-SO 2 —R 11 , -alk-SO 2 —CH═CH—R 11 or Het substituted with —SO 2 —R 11 or a phenyl radical substituted with —SO 2 —R 11 or -alk-SO 2 —R 11 , R 5 represents a hydrogen atom or an alkyl radical, R6 represents a phenylalkyl, Het or Ar radical, to the novel derivatives of formula (I) and to their preparation.

  本发明涉及包含作为活性成分的公式1化合物的药物组合物：其中R1代表—NHCOR4或—N(R5)—Y—R6，Y是CO或SO2，R4代表—alk-SO2—R11，-alk-SO2—CH═CH—R11或Het，或用—SO2—R11或—SO2—R11或-alk-SO2—R11取代的苯基自由基，R5代表氢原子或烷基自由基，R6代表苯基烷基，Het或Ar自由基，以及新颖的公式(I)衍生物及其制备方法。
• Azetidine derivatives, their preparation and pharmaceutical compositions containing them
  申请人：——

  公开号：US20010027193A1

  公开（公告）日：2001-10-04

  Compounds of formula: 1 in which R represents a CR 1 R 2 , C═C(R 5 )SO 2 R 6 or C═C(R 7 )SO 2 alk radical, their preparation and the pharmaceutical compositions containing them.

  式1中R代表CR1R2、C═C(R5)SO2R6或C═C(R7)SO2烷基基团，它们的制备以及含有它们的药物组合物。
• Pharmacological uses of azetidine derivatives
  申请人：Achard Daniel

  公开号：US20050130953A1

  公开（公告）日：2005-06-16

  A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula: in which R, R 3 and R 4 are as defined in the specification.

  一种治疗或预防阿尔茨海默病、帕金森病和/或精神分裂症的方法，该方法包括向需要此类治疗的患者施用以下化合物：其中R、R3和R4如规范中所定义。
• Novel benzamidoxime derivatives, intermediates and process for their preparation, and their use as fungicides
  申请人：——

  公开号：US20030078437A1

  公开（公告）日：2003-04-24

  Benzamidoxime derivatives of the formula I 1 where: R 1 is hydrogen or fluorine, R 2 is phenyl-C 1 -C 6 -alkyl which may carry one or more substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy or C 1 -C 4 -haloalkoxy on the phenyl ring, or is thienyl-C 1 -C 4 -alkyl, which may carry one or more substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy or C 1 -C 4 -haloalkoxy, or is pyrazolyl-C 1 -C 4 -alkyl, which may carry one or more substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy or C 1 -C 4 -haloalkoxy, are prepared.

  制备公式I1的苯甲酰肼衍生物，其中：R1为氢或氟，R2为苯基-C1-C6-烷基，其可以在苯环上携带一种或多种取代基，所述取代基选择自卤素、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基或C1-C4-卤代烷氧基的群体中的一种或多种，或者为噻吩基-C1-C4-烷基，其可以在噻吩环上携带一种或多种取代基，所述取代基选择自卤素、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基或C1-C4-卤代烷氧基的群体中的一种或多种，或者为吡唑基-C1-C4-烷基，其可以在吡唑环上携带一种或多种取代基，所述取代基选择自卤素、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基或C1-C4-卤代烷氧基。
• Novel Compounds
  申请人：Hickey Deirdre Mary Bernadette

  公开号：US20090118313A1

  公开（公告）日：2009-05-07

  Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA 2 and are of use in treating atherosclerosis.

  式(I)的吡啶酮化合物是Lp-PLA2酶的抑制剂，并可用于治疗动脉粥样硬化。