2-Propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazo[4,5-b]pyridine 4N-oxide | 135069-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazo[4,5-b]pyridine 4N-oxide
• 英文别名: 2-n-Propyl-1-[{2'-(1H-tetrazol-5-yl)biphenyl-4-yl}methyl]-1H-imidazo[4,5-b]pyridine；2-propyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine
• CAS: 135069-77-1
• 化学式: C₂₃H₂₁N₇
• 分子量: 395.467
• InChiKey: GBSZSEFQLKHENZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Fused imidazole derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0434038A1

  公开（公告）日：1991-06-26

  Novel fused imidazole derivatives of the formula (I): wherein the ring A, which may be optionally substituted, is a six-membered heteroaromatic group having one or two hetero nitrogen atoms; R¹ is hydrogen or an alkyl, aralkyl or aryl group which may be optionally substituted; R² is hydrogen, halogen or nitro; R³ is a residue capable of forming an anion or a residue convertible into an anion; X is a direct bond or a spacer-having atomic length of two or less; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof have potent angiotensin II antagonist activity and hypotensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

  新型融合的咪唑衍生物的化学式（I）：其中，环A是一个可能被取代的六元杂芳基团，具有一个或两个杂原子；R¹是氢或一个可以选择性取代的烷基、芳基或芳基烷基；R²是氢、卤素或硝基；R³是能够形成负离子的残基或可转化为负离子的残基；X是直接键或具有原子长度为两个或更少的间隔子；n是1或2的整数；其药学上可接受的盐具有强大的抗血管紧张素II活性和降压活性，因此可用作治疗循环系统疾病如高血压疾病、心脏疾病、中风等的治疗剂。
• Biphenylmethane derivative, the use of it and pharmacological compositions containing same
  申请人：Eisai Co., Ltd.

  公开号：EP0420237A1

  公开（公告）日：1991-04-03

  The biphenylmethane derivative having the formula (I) is disclosed

  公开了具有式 (I) 的联苯甲烷衍生物
• Biphenylmethane derivatives, the use of them and pharmacological compositions containing same
  申请人：Eisai Co., Ltd.

  公开号：EP0628557A1

  公开（公告）日：1994-12-14

  Disclosed are biphenylmethane derivatives having the formula:    wherein    R² and R³, which may be the same or different, are each a hydrogen atom, a halogen atom, a lower C₁₋₆ alkyl group a lower C₁₋₆ alkoxy group, a carbamoyl group or a cyano group;    R⁴ stands for hydrogen or a lower C₁₋₆ alkyl group;    R⁵ is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof;    R⁶ stands for hydrogen, a halogen atom, a hydroxy group or a lower C₁₋₆ alkoxy group, or a pharmacologically acceptable salt thereof,    wherein    compounds having the following formula and their pharmacologically acceptable salts are excluded:    wherein R⁵ is 1H-tetrazol-5-yl, a carboxyl (-COOH) group or a carboxylic ester thereof and n is an integer of 1 to 2;    or a pharmacologically acceptable salt thereof. Further, a process for their preparation, pharmaceutical compositions containing same and their use for the preparation of such compositions for preventing and treating hypertension and/or cardiac failure are disclosed.

  所公开的是具有以下式子的联苯甲烷衍生物： 其中 R²和R³可以相同或不同，各自为氢原子、卤素原子、低级C₁₋₆烷基、低级C₁₋₆烷氧基、氨基甲酰基或氰基； R⁴ 代表氢或低级 C₁₋₆ 烷基； R⁵ 是 1H-四唑-5-基、羧基 (-COOH) 或其羧酸酯； R⁶ 代表氢、卤素原子、羟基或低 C₁₋₆ 烷氧基，或其药理学上可接受的盐、 其中 具有下式的化合物及其药理学上可接受的盐除外： 其中 R⁵ 是 1H-四唑-5-基、羧基（-COOH）或其羧酸酯，n 是 1 至 2 的整数； 或其药理学上可接受的盐。 此外，还公开了它们的制备工艺、含有它们的药物组合物以及制备这种组合物用于预防和治疗高血压和/或心力衰竭的用途。
• US5298518A
  申请人：——

  公开号：US5298518A

  公开（公告）日：1994-03-29
• US5328911A
  申请人：——

  公开号：US5328911A

  公开（公告）日：1994-07-12