2-(2'-iodophenylamino)isophthalic acid | 98370-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2'-iodophenylamino)isophthalic acid
• 英文别名: 2-(2-iodoanilino)benzene-1,3-dicarboxylic acid
• CAS: 98370-33-3
• 化学式: C₁₄H₁₀INO₄
• 分子量: 383.142
• InChiKey: DQSXUFXHVGLMEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.43
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.63
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(2'-iodophenylamino)isophthalic acid 在 PPA 作用下， 反应 2.0h， 以82%的产率得到9,10-dihydro-5-iodo-9-oxoacridine-4-carboxylic acid
  参考文献：
  名称：

  The Synthesis of Substituted 9-Oxoacridan-4-carboxylic Acids; Part 2. The Use of 2-lodoisophthalic Acid in the Jourdan-Ullmann Reaction

  摘要：

  DOI：

  10.1055/s-1985-31164
• 作为产物：
  描述：

  2,6-二羧基苯胺 在 copper(l) chloride N-乙基吗啉 作用下， 以 苯 为溶剂， 反应 1.0h， 生成 2-(2'-iodophenylamino)isophthalic acid
  参考文献：
  名称：

  The Synthesis of Substituted 9-Oxoacridan-4-carboxylic Acids; Part 2. The Use of 2-lodoisophthalic Acid in the Jourdan-Ullmann Reaction

  摘要：

  DOI：

  10.1055/s-1985-31164

文献信息

• Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma
  作者：Nicolas Desbois、Maryline Gardette、Janine Papon、Pierre Labarre、Aurélie Maisonial、Philippe Auzeloux、Claire Lartigue、Bernadette Bouchon、Eric Debiton、Yves Blache、Olivier Chavignon、Jean-Claude Teulade、Jean Maublant、Jean-Claude Madelmont、Nicole Moins、Jean-Michel Chezal

  DOI：10.1016/j.bmc.2008.07.015

  日期：2008.8

  Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [I-125] NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumour-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumour concentrations together with an in vivo kinetic pro. le favourable to application in targeted radionuclide therapy. (C) 2008 Elsevier Ltd. All rights reserved.
• REWCASTLE, G. W.;DENNY, W. A., SYNTHESIS, BRD, 1985, N 2, 217-220
  作者：REWCASTLE, G. W.、DENNY, W. A.

  DOI：——

  日期：——