(R)-3-((1-(6-tert-butylnicotinoyl)pyrrolidin-2-yl)methoxy)picolinamide | 1263504-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (R)-3-((1-(6-tert-butylnicotinoyl)pyrrolidin-2-yl)methoxy)picolinamide
• 英文别名: 3-[[(2R)-1-(6-tert-butylpyridine-3-carbonyl)pyrrolidin-2-yl]methoxy]pyridine-2-carboxamide
• CAS: 1263504-63-7
• 化学式: C₂₁H₂₆N₄O₃
• 分子量: 382.462
• InChiKey: AMNHECCRNKCCKH-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  98.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PICOLINAMIDE DERIVATIVES AS TTX-S BLOCKERS<br/>[FR] DÉRIVÉS DE PICOLINAMIDE BLOQUEURS DE TTX-S
  申请人：RAQUALIA PHARMA INC

  公开号：WO2011016234A1

  公开（公告）日：2011-02-10

  The present invention relates to picolinamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及对电压门控钠通道具有阻塞活性的吡啶甲酰胺衍生物，这些通道是TTX-S通道，对涉及电压门控钠通道的疾病和疾病的治疗或预防具有用处。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及电压门控钠通道的疾病中使用这些化合物和组合物。
• PICOLINAMIDE DERIVATIVES AS TTX-S BLOCKERS
  申请人：Noguchi Hirohide

  公开号：US20120142691A1

  公开（公告）日：2012-06-07

  The present invention relates to picolinamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及对电压门控钠通道（如TTX-S通道）具有阻断活性的吡哆酰胺衍生物，这些衍生物在治疗或预防涉及电压门控钠通道的疾病和疾病方面是有用的。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病方面的使用。
• US8809380B2
  申请人：——

  公开号：US8809380B2

  公开（公告）日：2014-08-19
• US8969383B2
  申请人：——

  公开号：US8969383B2

  公开（公告）日：2015-03-03