1-ethyl-3-(3-(4-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenylsulfonyl)piperazine-1-carbonyl)benzo[b]thiophen-2-yl)urea | 1067907-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-ethyl-3-(3-(4-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenylsulfonyl)piperazine-1-carbonyl)benzo[b]thiophen-2-yl)urea
• 英文别名: 1-Ethyl-3-[3-[4-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]sulfonylpiperazine-1-carbonyl]-1-benzothiophen-2-yl]urea
• CAS: 1067907-73-6
• 化学式: C₂₅H₂₆N₆O₅S₂
• 分子量: 554.651
• InChiKey: RMUFEHTZUQWNMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  174
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• ACETYL COENZYME A CARBOXYLASE INHIBITORS
  申请人：Chang Edcon

  公开号：US20090005375A1

  公开（公告）日：2009-01-01

  The present invention relates to acetyl coenzyme-A carboxylase (“ACC”) inhibiting compounds of the formula wherein the variables are as defined herein. In particular, the present invention relates to ACC1 and/or ACC2 inhibitors, compositions of matter, kits and articles of manufacture comprising these compounds, methods for inhibiting ACC1 and/or ACC2, and methods of making the inhibitors.
• [EN] ACETYL COENZYME A CARBOXYLASE INHIBITORS<br/>[FR] INHIBITEUR DE L'ACÉTYL-COA CARBOXYLASE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2008121592A2

  公开（公告）日：2008-10-09

  [EN] The present invention relates to acetyl coenzyme-A carboxylase ("ACC") inhibiting compounds of the Formula (I), wherein the variables are as defined herein. In particular, the present invention relates to ACC1 and/or ACC2 inhibitors, compositions of matter, kits and articles of manufacture comprising these compounds, methods for inhibiting ACC1 and/or ACC2, and methods of making the inhibitors.
  [FR] L'invention concerne des composés inhibiteurs de l'acétyl-CoA carboxylase (ACC) de la formule dans laquelle les variables sont telles que définies ici. En particulier, l'invention concerne des inhibiteurs de ACC1 et/ou ACC2, des compositions, des kits et articles de fabrication contenant ces composés, des procédés d'inhibition de ACC1 et/ou ACC2, et des procédés de réalisation des inhibiteurs.