(7-Methyl-2-naphthalen-2-ylimidazo[1,2-a]pyridin-3-yl)methanol | 440345-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (7-Methyl-2-naphthalen-2-ylimidazo[1,2-a]pyridin-3-yl)methanol
• CAS: 440345-76-6
• 化学式: C₁₉H₁₆N₂O
• 分子量: 288.349
• InChiKey: WWTZDULADFRZRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苄硫醇 、 (7-Methyl-2-naphthalen-2-ylimidazo[1,2-a]pyridin-3-yl)methanol 以 溶剂黄146 为溶剂， 反应 4.0h， 以75%的产率得到3-(Benzylsulfanylmethyl)-7-methyl-2-(2-naphthyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus

  摘要：

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00347-9
• 作为产物：
  描述：

  2-溴代-2-乙酰基萘 在 sodium acetate 作用下， 以 乙醇 、 水 、 溶剂黄146 为溶剂， 反应 8.0h， 生成 (7-Methyl-2-naphthalen-2-ylimidazo[1,2-a]pyridin-3-yl)methanol
  参考文献：
  名称：

  Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus

  摘要：

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00347-9

文献信息

• [EN] IMIDAZOPYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS IMIDAZOPYRIDINES
  申请人：PROXIMAGEN LTD

  公开号：WO2010064020A1

  公开（公告）日：2010-06-10

  The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.

  这项发明涉及式(I)的化合物及其药学上可接受的盐和溶剂化合物，这些化合物是SSAO活性的抑制剂。该发明还涉及包含这些化合物的药物组合物，以及利用这些化合物治疗或预防抑制SSAO活性有益的医疗状况，如炎症性疾病和免疫紊乱。
• Imidazopyridine Compounds
  申请人：Nilsson Marianne

  公开号：US20120010188A1

  公开（公告）日：2012-01-12

  The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.

  本发明涉及公式（I）的化合物及其药学上可接受的盐和溶剂化物，它们是SSAO活性抑制剂。本发明还涉及包含这些化合物的药物组合物和使用这些化合物治疗或预防抑制SSAO活性有益的医疗条件，例如炎症性疾病和免疫紊乱。
• IMIDAZOPYRIDINE COMPOUNDS
  申请人：Proximagen Limited

  公开号：US20150239905A1

  公开（公告）日：2015-08-27

  The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.

  本发明涉及式(I)的化合物及其药学上可接受的盐和溶剂，它们是SSAO活性的抑制剂。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物治疗或预防抑制SSAO活性有益的医疗状况，例如炎症性疾病和免疫障碍。
• Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus
  作者：Sylvie Mavel、Jean-Louis Renou、Christophe Galtier、Hassan Allouchi、Robert Snoeck、Graciella Andrei、Erik De Clercq、Jan Balzarini、Alain Gueiffier

  DOI：10.1016/s0968-0896(01)00347-9

  日期：2002.4

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.