(E)-N-propylideneaniline | 118793-04-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-propylideneaniline
• 英文别名: N-phenylpropan-1-imine
• CAS: 118793-04-7
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: WGTZFOHCKYJBMK-CSKARUKUSA-N

物化性质

• 沸点：
  210.4±13.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-N-propylideneaniline 生成 2-(苯基氨基)丁酸
  参考文献：
  名称：

  KATO, SHOZO

  摘要：

  DOI：
• 作为产物：
  描述：

  丙醛 、 苯胺 以 氘代乙腈 为溶剂， 生成 (E)-N-propylideneaniline
  参考文献：
  名称：

  Crampton, Michael R.; Lord, Simon D.; Millar, Ross, Journal of the Chemical Society. Perkin Transactions 2 (2001), 1997, # 5, p. 909 - 914

  摘要：

  DOI：

文献信息

• A New Synthesis of Imines via Grignard- and Cuprate Additions to<i>N</i>-Trimethylsilylformamides
  作者：Ben L. Feringa、Johan F. G. A. Jansen

  DOI：10.1055/s-1988-27507

  日期：——

  Various imines and some amines were synthesized by the addition of Grignard reagents, homo- and hetero-cuprates to N-silylated-, N-alkyl-or N-arylformamides 1.

  通过将格氏试剂、同源和异源铜化合物加入N-硅基化、N-烷基或N-芳基甲酰胺1，合成了多种亚胺和一些胺。
• Diastereoselective additions of lithiated N-tertbutyldiphenylsilyl- S-methyl-S-phenylsulfoximine to imines and aldehydes
  作者：Stephen G. Pyne、Branko Dikic

  DOI：10.1016/s0040-4039(00)97851-1

  日期：1990.1

  Lithiated N-tert-butyldiphenylsilyl-S-methyl-S-phenylsulfoximine undergoes 1,2 addition to imines (R1CHNPh) and aldehydes (RCHO) to give diastereomeric adducts. The diastereoselection of the former reactions is dependent on the steric demand of the imine substituent R1, while that of the latter is independent of the steric demand of the aldehyde substituent R.

  锂化的N-叔丁基二苯基甲硅烷基-S-甲基-S-苯基亚磺酰亚胺经过1,2加成的亚胺（R 1 CH = NPh）和醛（RCHO）生成非对映异构体加合物。前者的非对映选择性取决于亚胺取代基R 1的空间需求，而后者的则与醛取代基R的空间需求无关。
• [EN] PROCESS FOR OBTAINING 3,3-DIPHENYLPROPYLAMINES<br/>[FR] PROCÉDÉ POUR L'OBTENTION DE 3,3-DIPHÉNYLPROPYLAMINES
  申请人：RAGACTIVES S L U

  公开号：WO2011012584A1

  公开（公告）日：2011-02-03

  The invention relates to a process for obtaining 3,3- diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R1 is C1-C8 alkyl; and R3 and R4, independently of one another, represent H or C1-C8 alkyl, or together form a ring of 3 to 7 members with the nitrogen to which they are bound. The invention also relates to the compounds of formula (V), as well as their enantiomers, solvates and salts.

  该发明涉及一种用于获得通式（I）所示的3,3-二苯基丙胺，特别是非索特罗定（Fesoterodine）的过程，以及它们的对映体、溶剂合物和盐，包括在通式（V）所示化合物中对酸基进行化学选择性还原以对抗酯基，其中R1为C1-C8烷基；R3和R4，彼此独立地，代表H或C1-C8烷基，或者一起与它们结合的氮形成一个由3到7个成员组成的环。该发明还涉及通式（V）所示的化合物，以及它们的对映体、溶剂合物和盐。
• Addition of Trialkylalanes to Imines under Zirconium Catalysis
  作者：Jan Szymoniak、Clément Denhez、Jean-Luc Vasse

  DOI：10.1055/s-2005-870028

  日期：——

  Trialkylalanes, which are inert toward imines, undergo addition to them in the presence of a catalytic amount of dichloro­dicyclopentadienylzirconium(IV) (Cp2ZrCl2). The reaction tolerates the presence of several functional groups in the starting imine such as halo, amide, nitrile, and hydroxy groups. A possible reaction pathway is proposed involving metallacyclic intermediates.

  三烷基醛对亚胺是惰性的，在催化量的二氯二环戊二烯基锆（IV）（Cp2ZrCl2）的存在下，三烷基醛会与亚胺发生加成反应。该反应可以容忍起始亚胺中存在卤代、酰胺、腈和羟基等多个官能团。提出了一种涉及金属环中间体的可能反应途径。
• Ion channel modulators
  申请人：Zelle Robert

  公开号：US20070208070A1

  公开（公告）日：2007-09-06

  The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and treatment of disease and disease symptoms, particularly those mediated by certain calcium channel subtype targets.

  本发明涉及化合物、包含该化合物的组合物以及使用该化合物和化合物组合物的方法。本文所描述的化合物、组合物和方法可用于治疗离子通道功能的治疗调节，以及治疗疾病和疾病症状，特别是由某些钙通道亚型靶点介导的疾病。