1-(2-Propylmercapto-ethyl)-pyrrolidin-2-on | 90949-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Propylmercapto-ethyl)-pyrrolidin-2-on
• 英文别名: 1-(2-propylsulfanyl-ethyl)-pyrrolidin-2-one；1-(2-Propylsulfanylethyl)pyrrolidin-2-one
• CAS: 90949-90-9
• 化学式: C₉H₁₇NOS
• 分子量: 187.306
• InChiKey: NHAOJFHPEFFASS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP0241050A2

  公开（公告）日：1987-10-14

  An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by the following formula wherein A is -CH2-or -S-for example, B is sulfur or oxygen, R is -SR" in which R" is an alkyl group or alkylthioalkyl group for example, or -OR" in which R" is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.

  一种用于促进药物吸收的氮杂环烷烃衍生物，一种包含至少一种氮杂环烷烃衍生物作为促进吸收有效成分的吸收促进剂，以及一种含有该吸收促进剂的外用制剂，该衍生物由下式表示 其中 A 是-CH2-或-S-例如，B 是硫或氧，R 是-SR"，其中 R "是烷基或烷硫烷基（例如），或-OR"，其中 R "如上定义，是烷基或取代的氨基，R'是氢原子、烷基或烷氧基（例如），m 是 0-5 的整数，n 是 1-15 的整数。
• US4882359A
  申请人：——

  公开号：US4882359A

  公开（公告）日：1989-11-21
• [EN] AZACYCLOALKANE DERIVATIVES, ABSORPTION PROMOTERS CONTAINING THE DERIVATIVES AS THE EFFECTIVE INGREDIENT AND EXTERNAL PREPARATIONS CONTAINING THE ABSORPTION PROMOTERS
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：WO1987006226A2

  公开（公告）日：1987-10-22

  (EN) An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by formula (I), wherein A is -CH2- or -S- for example, B is sulfur or oxygen, R is -SR'' in which R'' is an alkyl group or alkylthioalkyl group for example, or -OR'' in which R'' is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.(FR) Dérivés d'azacycloalkane utiles pour activer l'absorption d'un médicament, agent activant l'absorption et comprenant au moins un des dérivés d'azacycloalkane en tant qu'ingrédient efficace pour activer l'absorption, et préparation externe contenant ledit agent d'activation d'absorption, le dérivé ci-décrit étant représenté par la formule (I) dans laquelle A est -CH2- ou -S- par exemple, B est soufre ou oxygène, R est -SR'' où R'' est un groupe alkyle ou un groupe alkylthioalkyle par exemple, ou bien -OR'' où R'' est tel que défini ci-dessus, un groupe alkyle ou un groupe amino substitué, R' est un atome d'hydrogène, un groupe alkyle ou un groupe alkyloxy par exemple, m est un entier de 0 à 5 et n est un entier de 1 à 15.