5,7-dimethyl-3-[(4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine | 1204925-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,7-dimethyl-3-[(4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]pyrazolo[1,5-a]pyrimidine
• 英文别名: (5,7-Dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-[4-[4-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]methanone
• CAS: 1204925-75-6
• 化学式: C₂₀H₂₀F₃N₅O₃S
• 分子量: 467.472
• InChiKey: YBYUXFZJZWRDGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  96.3
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Novel Derivatives
  申请人：Heer Jag Paul

  公开号：US20100016330A1

  公开（公告）日：2010-01-21

  The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Ca v 2.2 calcium channels is beneficial.

  本发明涉及新颖的哌嗪衍生物；其制备方法；含有这些衍生物的药物组合物；以及利用这些衍生物在治疗中治疗阻断Ca v 2.2钙通道有益的疾病。
• PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES
  申请人：Convergence Pharmaceuticals Limited

  公开号：EP2313413B1

  公开（公告）日：2012-05-16
• US8093249B2
  申请人：——

  公开号：US8093249B2

  公开（公告）日：2012-01-10
• [EN] PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRAZOLO[1,5-A]PYRIMIDINE
  申请人：GLAXO GROUP LTD

  公开号：WO2010007074A1

  公开（公告）日：2010-01-21

  The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.