1-Ethyl-pyrrolidin-2-ylamine | 45515-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Ethyl-pyrrolidin-2-ylamine
• 英文别名: 1-Ethyl-2-pyrrolidinamine；1-ethylpyrrolidin-2-amine
• CAS: 45515-54-6
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: KTHAOBTZABTOCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE
  申请人：Gray Nathanael S.

  公开号：US20110312908A1

  公开（公告）日：2011-12-22

  The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.

  本发明提供了一种新型的杂环芳基化合物，该化合物通过胺连接剂与芳基基团相连。这些化合物对于治疗癌症具有实用价值。
• Small molecule myristate inhibitors of BCR-ABL and methods of use
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10787455B2

  公开（公告）日：2020-09-29

  The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.

  本发明提供了式(I)的新型杂芳基化合物，该化合物具有一个含嘧啶的核心，该核心通过胺连接体与一个 4-三氟甲氧基苯基连接。此类化合物可用于治疗癌症。
• Small molecule myristate inhibitors of Bcr-abl and methods of use
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11254682B2

  公开（公告）日：2022-02-22

  The present disclosure provides novel heteroaryl compounds of formula (IV). Such compounds are useful for the treatment of cancers.

  本公开提供了新型的式(IV)杂芳基化合物。此类化合物可用于治疗癌症。
• Chemical system with self-timing indicator
  申请人：Arndt Douglas C.

  公开号：US20090068116A1

  公开（公告）日：2009-03-12

  A luminescent composition, with a luminescent marker and a ionizing agent exhibiting luminescence for an indicatory period once intermixed, and with luminance intensity remaining at a threshold intensity during indicatory period. Luminescence also can be exhibited responsive to responsive to excitatory light applied to the composition. The luminescent marker includes a coumarinic compound and the ionizing agent includes an ammonium base. Antimicrobial agents are included. A luminescence measuring apparatus includes a photoemitter and a photodetector responsive to an emissive light induced by photoemitter. An optical filter can be used with the photodetector. A two-phase composition dispensing apparatus includes a first phase reservoir, a second phase reservoir, a mixing nozzle, and a dispensing mechanism.
• CHEMICAL SYSTEM WITH SELF-TIMING INDICATOR
  申请人：Arndt Douglas C.

  公开号：US20120214879A1

  公开（公告）日：2012-08-23

  A pH-modified luminescent composition and methods. In composition, a marker exhibiting luminescence change over a indicatory period. pH-based luminesce change may be in intensity or in wavelength. One embodiment provides a luminescent composition, including a selected luminescent marker having a first phase; and a selected ionizing agent comprising a second phase. The selected luminescent marker exhibits luminescence for an indicatory period responsive to intermixing of the first phase with the second phase. A selected antimicrobial agent combined with the first phase of the luminescent composition, wherein intermixing of the first phase with the second phase is at least a portion of a hand hygiene protocol. A method embodiment of using the luminescent composition, can include providing a luminescent marker; providing a ionizing agent; intermixing the luminescent marker with the ionizing agent; causing a change in pH in the selected luminescent marker; and exhibiting luminescence for a predetermined indicatory period.