Benzoic acid (2R,4R,5S)-4,5-dimethoxy-3-oxo-tetrahydro-furan-2-ylmethyl ester | 58366-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid (2R,4R,5S)-4,5-dimethoxy-3-oxo-tetrahydro-furan-2-ylmethyl ester
• 英文别名: [(2R,4R,5S)-4,5-dimethoxy-3-oxooxolan-2-yl]methyl benzoate
• CAS: 58366-25-9
• 化学式: C₁₄H₁₆O₆
• 分子量: 280.277
• InChiKey: JSSPGYNUHMBQNX-OSMZGAPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES
  申请人：Chun Byoung Kwon

  公开号：US20170253584A1

  公开（公告）日：2017-09-07

  The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
• US8481713B2
  申请人：——

  公开号：US8481713B2

  公开（公告）日：2013-07-09
• US8637475B1
  申请人：——

  公开号：US8637475B1

  公开（公告）日：2014-01-28