3,5-bis(chloromethyl)-2,4,6-trimethylbenzene | 135963-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis(chloromethyl)-2,4,6-trimethylbenzene
• 英文别名: 2,4,6-trimethyl-3,5-bis(chloromethyl)benzaldehyde；2,4,6-Trimethyl-3,5-bis(chloro-methyl)benzaldehyde；3,5-bis(chloromethyl)-2,4,6-trimethylbenzaldehyde
• CAS: 135963-00-7
• 化学式: C₁₂H₁₄Cl₂O
• 分子量: 245.149
• InChiKey: MCPUMBYJIOFVJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,5-bis(chloromethyl)-2,4,6-trimethylbenzene 在 五氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以98%的产率得到3,5-bis(chloromethyl)-2,4,6-trimethylbenzylidene dichloride
  参考文献：
  名称：

  Unusual effects of steric hindrances in NMR spectra of o,o′-dialkylsubstituted benzylidene dichlorides

  摘要：

  It has been found that steric hindrances of the CHCl2 group rotation around C(Ar)-CHCl2 bond in o,o'-dialkylsubstituted benzylidene dichlorides call forth a non-equivalence of the alkyls in positions 2 and 6. The non-equivalence displays in H-1 and C-13 NMR spectra at room temperature and at -20 degrees-C. At the latter temperature, the spectra of 2,4,6-trimethyl-3-chloromethylbenzylidene dichloride and bis(dichloromethyl)mesitylene indicate the presence of two conformations, the assignment of signals having been accomplished for each of them.

  DOI：

  10.1016/s0040-4020(01)87135-0
• 作为产物：
  描述：

  1,1-二氯甲醚 、 2,4-双(氯甲基)三甲基苯 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以66%的产率得到3,5-bis(chloromethyl)-2,4,6-trimethylbenzene
  参考文献：
  名称：

  Unusual effects of steric hindrances in NMR spectra of o,o′-dialkylsubstituted benzylidene dichlorides

  摘要：

  It has been found that steric hindrances of the CHCl2 group rotation around C(Ar)-CHCl2 bond in o,o'-dialkylsubstituted benzylidene dichlorides call forth a non-equivalence of the alkyls in positions 2 and 6. The non-equivalence displays in H-1 and C-13 NMR spectra at room temperature and at -20 degrees-C. At the latter temperature, the spectra of 2,4,6-trimethyl-3-chloromethylbenzylidene dichloride and bis(dichloromethyl)mesitylene indicate the presence of two conformations, the assignment of signals having been accomplished for each of them.

  DOI：

  10.1016/s0040-4020(01)87135-0

文献信息

• [EN] AMINE SYNERGISTS<br/>[FR] SYNERGISTES AMINES
  申请人：HEWLETT PACKARD DEVELOPMENT CO

  公开号：WO2018143923A1

  公开（公告）日：2018-08-09

  The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.

  本公开涉及一种胺协同剂，包括一种包括带有取代苯环的三级苄胺的胺。该三级胺可以通过多个水溶性基团进行修饰。
• Synthesis of sterically hindered aromatic aldehydes
  作者：A. P. Yakubov、D. V. Tsyganov、L. I. Belen'kii、M. M. Krayushkin

  DOI：10.1007/bf00961246

  日期：1991.7

  Formylation of mesitylene, durene, and m-xylene derivatives containing electron-donor and electron-acceptor substituents by dichloromethyl methyl ether was studied in the presence of TiCl4. A series of functionally substituted sterically hindered benzaldehydes was prepared from the products of these reactions.
• YAKUBOV, A. P.;TSYGANOV, D. V.;BELENKIJ, L. I.;KRAYUSHKIN, M. M., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 1609-1615
  作者：YAKUBOV, A. P.、TSYGANOV, D. V.、BELENKIJ, L. I.、KRAYUSHKIN, M. M.

  DOI：——

  日期：——