N,N'-bis[3-(3-ferroceneacetylaminopropyl)methylaminopropyl]naphthalene-1,4,5,8-tetracarboxylic acid diimide | 344315-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N'-bis[3-(3-ferroceneacetylaminopropyl)methylaminopropyl]naphthalene-1,4,5,8-tetracarboxylic acid diimide
• 英文别名: N,N'-bis[3-(3-ferroceneacetamidopropyl)methylaminopropyl]-naphthalene-1,4,5,8-tetracarboxylic acid diimide；cyclopenta-1,3-diene;2-cyclopenta-2,4-dien-1-yl-N-[3-[3-[13-[3-[3-[(2-cyclopenta-2,4-dien-1-ylacetyl)amino]propyl-methylamino]propyl]-5,7,12,14-tetraoxo-6,13-diazatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl-methylamino]propyl]acetamide;iron(2+)
• CAS: 344315-56-6
• 化学式: C₅₂H₅₈Fe₂N₆O₆
• 分子量: 974.763
• InChiKey: HQISOGHGHOUBDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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反应信息

• 作为产物：
  描述：

  二茂铁基乙酸 、 N,N'-bis[3-(3-aminopropyl)methylaminonpropyl]-naphthalene-1,4,5,8-tetracarboxylic acid diimide 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 氯仿 为溶剂， 以20%的产率得到N,N'-bis[3-(3-ferroceneacetylaminopropyl)methylaminopropyl]naphthalene-1,4,5,8-tetracarboxylic acid diimide
  参考文献：
  名称：

  Ferrocenyl naphthalene diimide can bind to DNA·RNA hetero duplex: potential use in an electrochemical detection of mRNA expression

  摘要：

  The novel ferrocenyl naphthalene diimide derivative I was synthesized by the condensation reaction between ferroceneacetic acid and terminal amino moieties of two imide substituents of naphthalene diimide. Stopped-flow analysis of the ligand I and DNA interaction revealed the following results: (i) the ligand binds to double stranded DNA more strongly than to single stranded DNA; (ii) the ligand does not have a bias against DNA sequence; (iii) the ligand can bind to the DNA-RNA hetero duplex more strongly than to the DNA-DNA duplex. These properties of I make it a suitable ligand for analysis of not only DNA but RNA. In fact, a current due to I was observed at 269 mV in the differential pulse voltammetric analysis of dA(20)-immobilized electrode in an electrolyte containing 1. The current increased markedly upon hybridization with polyU, whereas no current increase was obtained for polyA. Since the DNA-RNA hetero duplex is formed between sample RNA and DNA on the electrode, I may be used for the electrochemical detection of mRNA expression. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(01)00951-2