3,6-di-O-acetyl-1,5-anhydro-2,4-dideoxy-D-threitol | 1064270-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 3,6-di-O-acetyl-1,5-anhydro-2,4-dideoxy-D-threitol
• 英文别名: [(2S,4R)-4-acetyloxyoxan-2-yl]methyl acetate
• CAS: 1064270-59-2
• 化学式: C₁₀H₁₆O₅
• 分子量: 216.234
• InChiKey: HIZFDOAIBLMYPP-ZJUUUORDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,6-di-O-acetyl-4-deoxy-2-O-tosyl-α-D-xylohexopyranosyl bromide 在 镍 氢气 、 三乙胺 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以64%的产率得到3,6-di-O-acetyl-1,5-anhydro-2,4-dideoxy-D-threitol
  参考文献：
  名称：

  Two Unusual Carbohydrate Reactions: Nucleophilic Ring Opening of an Anhydrosugar and Reductive Elimination with Co‐occurring Hydrogenation

  摘要：

  Treatment of the 1,6-anhydrosugar epoxide 5 with a cyano-Gilman cuprate [(CuCN (6 eq.), MeLi (12 eq.)] surprisingly led to the open chain rearranged (2S,3R)-1,2-dihydroxy-3,6-dimethylheptan-4-one (7), structurally confirmed by conversion to the corresponding diacetate 8. Another unusual reaction was found by hydrogenation of the 2-tosyl-1-bromosugar 11, leading in one operation to the twofold deoxygenated chiral pyran derivative 14. This procedure might prove to be useful in the rapid deoxygenation of sugar derivatives.

  DOI：

  10.1080/07328300802272389

文献信息

• [EN] STABILIZATION OF BIOMOLECULES USING SUGAR POLYMERS<br/>[FR] STABILISATION DE BIOMOLÉCULES AU MOYEN DE POLYMÈRES DE GLUCIDES
  申请人：UNIV CALIFORNIA

  公开号：WO2013112897A1

  公开（公告）日：2013-08-01

  Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.

  揭示了用于稳定生物分子的组合物和方法。具体来说，这些组合物包括含有与生物分子共轭的海藻糖侧链的新型同聚物或共聚物。当这种同聚物或共聚物与生物分子（如蛋白质）放置在紧密接触时，同聚物或共聚物可以保护和/或稳定生物分子。这些组合物和方法可能适用于各种行业，如医疗保健（制药）、分子生物学、生物燃料、纸张、个人护理、洗涤剂、摄影、橡胶、酿造、乳制品和食品加工行业。
• [EN] NEW CATECHOLAMINE PRODRUGS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASES<br/>[FR] NOUVEAUX PROMÉDICAMENTS DE CATÉCHOLAMINE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES DE PARKINSON
  申请人：H LUNDBECK AS

  公开号：WO2020234275A1

  公开（公告）日：2020-11-26

  The present invention provides compounds of formula (Id) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.

  本发明提供了化合物（Id）的公式，这些化合物是儿茶酚胺的前药，用于治疗神经退行性疾病和紊乱。本发明还提供了包括本发明化合物的药物组合物以及使用本发明化合物治疗神经退行性或神经精神疾病和紊乱的方法，特别是帕金森病。
• SUBSTITUTED POLYESTERS BY THIOL-ENE MODIFICATION: RAPID DIVERSIFICATION FOR THERAPEUTIC PROTEIN STABILIZATION
  申请人：The Regents of the University of California

  公开号：EP3342796A1

  公开（公告）日：2018-07-04

  Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5-[R1R2C - CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (-OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

  本发明公开了可生物降解的三卤糖共聚物的结构和制造方法。具体来说，可生物降解的三卤糖共聚物由一般结构 R5-[R1R2C-CR3R4]n-[DG]m-R6组成，其中 R1-R4 独立地选自氢或包含至少一个碳原子的侧链、其中 R1-R4 中至少有一个是由-L-曲哈糖组成的侧链，其中 L 是连接分子，通过至少一个曲哈糖羟基（-OH）将曲哈糖与单体连接，其中 DG 是可生物降解基团，其中 R5 和 R6 是端基。
• Steroids and protein-conjugates thereof
  申请人：Regeneron Pharmaceuticals, Inc.

  公开号：US10711032B2

  公开（公告）日：2020-07-14

  Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

  本文描述的蛋白质类固醇共轭物可用于向细胞靶向输送糖皮质激素（GCs）等。
• SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF
  申请人：Alectos Therapeutics, Inc.

  公开号：EP2638052B1

  公开（公告）日：2017-03-22