2-(4-chlorophenyl)-4,6-dimethoxybenzofuran-3(2H)-one | 1403682-27-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(4-chlorophenyl)-4,6-dimethoxybenzofuran-3(2H)-one
• 英文别名: 2-(4-Chlorophenyl)-4,6-dimethoxy-1-benzofuran-3-one
• CAS: 1403682-27-8
• 化学式: C₁₆H₁₃ClO₄
• 分子量: 304.73
• InChiKey: GZZVHADBGVORBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(4-chlorophenyl)-4,6-dimethoxybenzofuran-3(2H)-one 在 苄基三甲基氢氧化铵 、 zinc(II) iodide 作用下， 以 甲醇 、 乙腈 、 叔丁醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Flavaglines as Potent Anticancer and Cytoprotective Agents

  摘要：

  Flavaglines represent a family of plant natural products that display potent anticancer, Cardioprotective, and neuroprotective activities. Novel flavagline derivatives were synthesized and examined for their cytotoxicity on a panel of human cancer cell lines, their cardioprotection against doxorubicin-induced apoptosis in cardiomyocytes, and their neuroprotection in culture models of Parkinson's disease and cisplatin-induced neurotoxicity. The structural requirements of flavaglines for cardio and neuroprotection were for the first time unraveled and appeared to be slightly different from those for cytotoxicity on cancer cells. We provide also the first evidence that flavaglines may alleviate cisplatin-induced neurotoxicity, suggesting a prophylactic potential of these compounds to prevent this frequently encountered adverse effect of cancer chemotherapies.

  DOI：

  10.1021/jm301201z
• 作为产物：
  描述：

  2-(4-chlorophenyl)-2-(3,5-dimethoxyphenoxy)acetic acid 在 zinc(II) chloride 、 三氯氧磷 作用下， 以72 %的产率得到2-(4-chlorophenyl)-4,6-dimethoxybenzofuran-3(2H)-one
  参考文献：
  名称：

  WO2023/30685

  摘要：

  公开号：