7-[(benzyloxy)methyl]-4-chloro-7H-pyrrolo[2,3-d]pyrimidine | 1236033-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 7-[(benzyloxy)methyl]-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
• 英文别名: 4-chloro-7-(phenylmethoxymethyl)pyrrolo[2,3-d]pyrimidine
• CAS: 1236033-22-9
• 化学式: C₁₄H₁₂ClN₃O
• 分子量: 273.722
• InChiKey: GDGCYBRLLIQOML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苄基氯甲基醚 、 4-氯吡咯并嘧啶 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 1.33h， 以70.7%的产率得到7-[(benzyloxy)methyl]-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
  参考文献：
  名称：

  PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS

  摘要：

  本发明涉及制备手性取代吡唑基吡咯并[2,3-d]嘧啶的公式III的过程，以及相关的合成中间体化合物。这些手性取代吡唑基吡咯并[2,3-d]嘧啶可用作抑制Janus激酶家族蛋白酪氨酸激酶（JAKs）的药物，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。

  公开号：

  US20100190981A1

文献信息

• [EN] PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS<br/>[FR] PROCÉDÉS DE PRÉPARATION D'INHIBITEURS DES JAK ET COMPOSÉS INTERMÉDIAIRES APPARENTÉS
  申请人：INCYTE CORP

  公开号：WO2010083283A2

  公开（公告）日：2010-07-22

  The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-di]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备手性取代的Formula III的吡唑基吡咯并[2,3-di]嘧啶化合物的过程，以及相关的合成中间体化合物。手性取代的吡唑基吡咯并[2,3-d]嘧啶化合物可用作Janus激酶家族的蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Processes for preparing JAK inhibitors and related intermediate compounds
  申请人：Zhou Jiacheng

  公开号：US08883806B2

  公开（公告）日：2014-11-11

  The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备手性取代的Formula III式吡唑基吡咯[2,3-d]嘧啶的过程，以及相关的合成中间体化合物。手性取代的吡唑基吡咯[2,3-d]嘧啶可用作Janus激酶家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
  申请人：Incyte Holdings Corporation

  公开号：US10364248B2

  公开（公告）日：2019-07-30

  The present invention is related to processes for preparing 4-chloro-7H-pyrollo[2,3,-d]pyrimidine, and related synthetic intermediate compounds. 4-Chloro-7H-pyrrolo[2,3,-d]pyrimidine is an intermediate for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines, which are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备 4-氯-7H-吡咯并[2,3,-d]嘧啶和相关合成中间体化合物的工艺。4-氯-7H-吡咯并[2,3,-d]嘧啶是制备手性取代的吡唑基吡咯并[2,3-d]嘧啶的中间体，可用作蛋白酪氨酸激酶 Janus Kinase 家族（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III
  申请人：Incyte Holdings Corporation

  公开号：US10975085B2

  公开（公告）日：2021-04-13

  The present invention is related to processes for preparing a composition comprising (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile, and related synthetic intermediate compounds. This compound is useful as an inhibitor of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备包含(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈及相关合成中间体化合物的组合物的工艺。该化合物可作为蛋白酪氨酸激酶 Janus Kinase 家族（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Processes for Preparing Jak Inhibitors and Related Intermediate Compounds
  申请人：Incyte Holdings Corporation

  公开号：US20210253584A1

  公开（公告）日：2021-08-19

  The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.