2-Nitranethylbenzolsaeure | 19814-01-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Nitranethylbenzolsaeure
• 英文别名: o-Carboxyphenylnitromethan；2-(nitromethyl)benzoic acid
• CAS: 19814-01-8
• 化学式: C₈H₇NO₄
• 分子量: 181.148
• InChiKey: GUSRPGBTLCRARI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SOLID FORMS COMPRISING 3-(4-AMINO-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] FORMES SOLIDES COMPRENANT DE LA 3-(4-AMINO-1-OXO-1,3-DIHYDRO-ISO-INDOL-2-YL)-PIPÉRIDINE-2,6-DIONE ET UN COAGENT DE FORMATION, COMPOSITIONS ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：CELGENE CORP

  公开号：WO2014160686A1

  公开（公告）日：2014-10-02

  Provided herein are solid forms comprising (a) 3-(4-amino-l-oxo-l,3- dihydro-isoindol-2-yl)-piperidine-2,6-dione (Lenalidomide) and (b) a coformer. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed.

  本文提供了包含(a) 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)-哌啶-2,6-二酮（来那度胺）和(b) 辅基的固体形式。还披露了包含这些固体形式的药物组合物以及治疗、预防和管理各种疾病的方法。
• Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levels
  申请人：CELGENE CORPORATION

  公开号：EP2859895A1

  公开（公告）日：2015-04-15

  Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.

  2-(2,6-二氧代哌啶-3-基)邻苯二甲酰亚胺和1-氧代-2-(2,6-二氧代哌啶-3-基)异吲哚烷可以降低哺乳动物体内的TNFα水平。典型的实施例包括1-氧代-2-(2,6-二氧代-3-甲基哌啶-3-基)-4,5,6,7-四氟异吲哚烷和1,3-二氧代-2-(2,6-二氧代-3-甲基哌啶-3-基)-4-氨基异吲哚烷。
• Substituted 2-(2,6-Dioxopiperidin-3-yl)-phthalimides and 1-Oxoisoindolines and Method of Reducing TNFalpha Levels
  申请人：Muller George W.

  公开号：US20130030021A1

  公开（公告）日：2013-01-31

  Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.

  本文披露了2-(2,6-二氧代哌啶-3-基)邻苯二酰亚胺和1-氧代-2-(2,6-二氧代哌啶-3-基)异吲哚烷的替代物。这些化合物在降低哺乳动物体内TNFα水平方面具有用途。
• Methods for the treatment of cachexia
  申请人：Muller W. George

  公开号：US20060160854A1

  公开（公告）日：2006-07-20

  Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.

  本文披露了2-(2,6-二氧杂环戊酰亚胺基)邻苯二酰亚胺和1-氧代-2-(2,6-二氧杂环戊酰亚胺基)异吲哚啉。这些化合物可用于例如降低哺乳动物体内TNFα水平的目的。
• Substituted 2-(2,6-dioxopiperidin-3-YL)-phthalimides and -1-oxoisoindolines and method of reducing TNFalpha levels
  申请人：——

  公开号：US20020183360A1

  公开（公告）日：2002-12-05

  Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF&agr; in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.

  2-(2,6-二氧代哌啶-3-基)邻苯二甲酰亚胺和1-氧代-2-(2,6-二氧代哌啶-3-基)异吲哚烷降低哺乳动物体内TNF&agr;水平。典型实施例包括1-氧代-2-(2,6-二氧代-3-甲基哌啶-3-基)-4,5,6,7-四氟异吲哚烷和1,3-二氧代-2-(2,6-二氧代-3-甲基哌啶-3-基)-4-氨基异吲哚烷。