1-ethyl-2[N-(2-methoxy)benzoyl-N-{2-methoxy-3-(4stearoylpiperazinocarbonyl)oxypropyloxy}carbonyl]aminomethylpyridinium iodide | 128400-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-ethyl-2[N-(2-methoxy)benzoyl-N-{2-methoxy-3-(4stearoylpiperazinocarbonyl)oxypropyloxy}carbonyl]aminomethylpyridinium iodide
• 英文别名: 1-ethyl-2-[N-(2-methoxy)benzoyl-N-{2-methoxy-3-(4-stearoylpiperazinocarbonyl)oxypropoxy}carbonyl]aminomethylpyridinium iodide；[3-[(1-Ethylpyridin-1-ium-2-yl)methyl-(2-methoxybenzoyl)carbamoyl]oxy-2-methoxypropyl] 4-octadecanoylpiperazine-1-carboxylate;iodide
• CAS: 128400-52-2
• 化学式: C₄₄H₆₉N₄O₈*I
• 分子量: 908.958
• InChiKey: XOOSZDKBAOVPRB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.34
• 重原子数：
  57
• 可旋转键数：
  28
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Organopathy preventing, curing or ameliorating agent
  申请人：Eisai Co., Ltd.

  公开号：EP0672415A1

  公开（公告）日：1995-09-20

  To provide an agent for preventing, curing or ameliorating organopathy attributed to reperfusion, ischemia or blood flow disorder in the organs such as liver, kidneys, heart, lungs, pancreas, blood vessels and small intestine, especially, those caused by transplantation and preservation of the organ and by blood reperfusion after transplantation and those occurring after surgical operation. An agent for preventing, curing or ameliorating organopathy of, for example, the liver, kidneys, heart, lungs, pancreas, blood vessels or small intestine, attributed to reperfusion, ischemia or blood flow disorder, comprising as an active ingredient a glycerol derivative represented by the following general formula or a pharmacologically acceptable salt thereof:

  提供一种药剂，用于预防、治疗或改善肝脏、肾脏、心脏、肺脏、胰腺、血管和小肠等器官由于再灌注、缺血或血流障碍而引起的器官病变，特别是由于移植和保存器官以及移植后血液再灌注引起的器官病变和外科手术后发生的器官病变。一种用于预防、治疗或改善由于再灌注、缺血或血流障碍引起的器官病变（例如肝脏、肾脏、心脏、肺、胰腺、血管或小肠）的制剂，其活性成分包括由以下通式代表的甘油衍生物或其药理学上可接受的盐：
• Glycerin derivative and its pharmacological use
  申请人：Eisai Co., Ltd.

  公开号：EP0353474B1

  公开（公告）日：1995-04-05
• ANGIOTENSIS CONVERTING ENZYME INHIBITORS
  申请人：FISONS plc

  公开号：EP0535042B1

  公开（公告）日：1995-03-29
• US5037827A
  申请人：——

  公开号：US5037827A

  公开（公告）日：1991-08-06
• US5476863A
  申请人：——

  公开号：US5476863A

  公开（公告）日：1995-12-19