3-(3',3'-Diphenyl-3'-oxy-1'-propinyl)quinuclidine | 106824-71-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3',3'-Diphenyl-3'-oxy-1'-propinyl)quinuclidine
• 英文别名: 3-(1-Azabicyclo[2.2.2]octan-3-yl)-1,1-diphenylprop-2-yn-1-ol
• CAS: 106824-71-9
• 化学式: C₂₂H₂₃NO
• 分子量: 317.431
• InChiKey: JZBPAABWDQDOMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-Vinylquinuclidine hydrochloride 在 溴 、 sodium amide 作用下， 以 水 为溶剂， 反应 5.0h， 生成 3-(3',3'-Diphenyl-3'-oxy-1'-propinyl)quinuclidine
  参考文献：
  名称：

  Amino alcohols of the acetylene series. IX. 3,3-Diphenyl-3-oxypropinyl-substituted quinuclidines

  摘要：

  DOI：

  10.1007/bf00763694

文献信息

• Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
  申请人：Guyaux Michel

  公开号：US20050020660A1

  公开（公告）日：2005-01-27

  The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention_show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.

  本发明涉及式I或II的季铵盐衍生物，其中取代基如规范中所定义，以及它们作为药物的用途。本发明的化合物具有高亲和力m3和/或m2胆碱能受体，特别适用于治疗尿失禁。
• LIBMAN N. M.; KUZNETSOV S. G.; GORCHAKOV V. S.; GOLIKOV S. N.; LEBEDEVA D+, XIM.-FARMATS. ZH., 20,(1986) N 11, 1308-1312
  作者：LIBMAN N. M.、 KUZNETSOV S. G.、 GORCHAKOV V. S.、 GOLIKOV S. N.、 LEBEDEVA D+

  DOI：——

  日期：——
• QUINUCLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS M2 AND/OR M3 MUSCARINIC RECEPTOR INHIBITORS
  申请人：UCB, S.A.

  公开号：EP1438309A1

  公开（公告）日：2004-07-21
• US7361668B2
  申请人：——

  公开号：US7361668B2

  公开（公告）日：2008-04-22
• [EN] QUINUCLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS M2 AND/OR M3 MUSCARINIC RECEPTOR INHIBITORS<br/>[FR] DERIVES DE QUINUCLIDINE, LEURS PROCEDES DE PREPARATION, ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS DE RECEPTEUR MUSCARINIQUE M2 ET/OU M3
  申请人：UCB SA

  公开号：WO2003033495A1

  公开（公告）日：2003-04-24

  The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention_show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.