1-乙基-3-氯-四氢吡咯 | 3608-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-乙基-3-氯-四氢吡咯
• 中文别名: 3-氯-1-乙基吡咯烷
• 英文名称: 1-Aethyl-3-chlor-pyrrolidin
• 英文别名: 3-Chloro-1-ethylpyrrolidine
• CAS: 3608-70-6
• 化学式: C₆H₁₂ClN
• 分子量: 133.621
• InChiKey: WDBPDIQNBCWYOY-UHFFFAOYSA-N

物化性质

• 沸点：
  157-159℃ (76 Torr)
• 密度：
  1.04±0.1 g/cm3 (20℃ 760 Torr)
• 闪点：
  52.7±25.4℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090
• 包装等级：
  III
• 危险类别：
  3
• 危险性防范说明：
  P210,P305+P351+P338
• 危险品运输编号：
  1993
• 危险性描述：
  H225,H315,H319,H335

文献信息

• Novel Methods for Preparation of (+)-1-ethyl-4-[2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone and Salts Thereof
  申请人：Dax Scott L.

  公开号：US20130109854A1

  公开（公告）日：2013-05-02

  The present invention includes a method of preparing a composition comprising (+)-doxapram or a salt thereof, wherein the composition is essentially free of (−)-doxapram or a salt thereof.

  本发明涉及一种制备含有(+)-多沙泮或其盐的组合物的方法，其中该组合物基本上不含(-)-多沙泮或其盐。
• Novel Method For Treating Breathing Disorders or Diseases
  申请人：Mannion James C.

  公开号：US20120101073A1

  公开（公告）日：2012-04-26

  The present invention includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising (+)-doxapram or a salt thereof, and a pharmaceutically acceptable carrier, wherein the formulation is essentially free of (−)-doxapram or a salt thereof.
• Novel Compositions and Therapeutic Methods Using Same
  申请人：Mannion James C.

  公开号：US20120270848A1

  公开（公告）日：2012-10-25

  The present invention includes compositions and methods for treating a subject in need of opioid therapy, wherein the opioid therapy produces or has the possibility of producing respiratory depression or a breathing control disorder in the subject.
• US5109013A
  申请人：——

  公开号：US5109013A

  公开（公告）日：1992-04-28
• [EN] NOVEL METHODS FOR TREATING BREATHING DISORDERS OR DISEASES<br/>[FR] NOUVELLES MÉTHODES DE TRAITEMENT DES TROUBLES OU DES MALADIES RESPIRATOIRES
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2012054813A1

  公开（公告）日：2012-04-26

  The present invention includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising (+)-doxapram or a salt thereof, and a pharmaceutically acceptable earner, wherein the formulation is essentially free of (— )-doxapram or a salt thereof.