Thymidin-5'-phosphit | 10059-17-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Thymidin-5'-phosphit
• 英文别名: [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxyphosphinic acid
• CAS: 10059-17-3
• 化学式: C₁₀H₁₅N₂O₇P
• 分子量: 306.212
• InChiKey: HYZIWFJILYVTQR-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS
  申请人：Cornell University

  公开号：EP3931346A1

  公开（公告）日：2022-01-05
• [EN] ISOLATED POLYNUCLEOTIDES ENCODING HUMAN 5'-NUCLEOTIDE CN-IA AND CN-IB, ISOLATED PROTEINS ENCODED BY THE SAME, AND METHODS UTILIZING THE SAME<br/>[FR] POLYNUCLEOTIDES ISOLES CODANT LES 5'-NUCLEOTIDASES CN-IA ET CN-IB HUMAINES, PROTEINES ISOLEES CODEES PAR CES POLYNUCLEOTIDES, ET PROCEDES D'UTILISATION
  申请人：UNIV NORTH CAROLINA

  公开号：WO2002004613A2

  公开（公告）日：2002-01-17

  The isolated polynucleotide sequence identified herein as SEQ ID NO: 1 encodes an human cytosolic 5'-nucleotidase form I (human cN-IA) and encodes the protein human cN-IA of SEQ ID NO:2. The isolated polynucleotide sequence identified herein as SEQ ID NO: 3 encodes a cytosolic 5'-nucleotidase form I (cN-IB) and encodes the protein cN-IB of SEQ ID NO:4. Expression of human cN-IA decreases the efficacy of antineoplastic drugs and increases the toxicity of AZT. Inhibitors of human cN-IA are useful in methods of treating cancer by increasing the efficacy of antineoplastic drugs, and in methods of treating viral infections such as HIV infection and AIDS by decreasing the side effects of AZT.
• [EN] USING TETHERED ENZYMES TO DETECT NUCLEIC ACIDS<br/>[FR] UTILISATION D'ENZYMES ATTACHÉES POUR DÉTECTER DES ACIDES NUCLÉIQUES
  申请人：UNIV CORNELL

  公开号：WO2020176638A1

  公开（公告）日：2020-09-03

  The present application relates to methods of detecting a target nucleic acid molecule in a sample. The method includes providing a sample containing a target nucleic acid molecule and a capture oligonucleotide molecule. In one embodiment, the capture oligonucleotide molecule has (i) a length of 30-60 base pairs, (ii) a 4-8 base pair overhang on its 3' end, (iii) a 5' tail, (iv) a target-specific portion between the 3' end and the 5' tail, (v) a deoxy-adenosine diphosphate content of 40-50%, (vi) no deoxy thymidine phosphate in the 3' end or the 5' tail, and (vii) the 3' end and the 5' tail having an ATP content which is 40-50% of that of the capture oligonucleotide molecule. In another aspect of the method of detecting, certain reagents are coupled to a solid support. The present application also relates to compositions and kits useful in carrying out the methods of the present application.