3-(5-(2-(2-(1,3-dioxaindan-5-yl)-5-methyloxazol-4-yl)ethoxy)-1,2,3,4-tetrahydroquinolin-1-yl)propanoic acid ethyl ester | 479252-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-(5-(2-(2-(1,3-dioxaindan-5-yl)-5-methyloxazol-4-yl)ethoxy)-1,2,3,4-tetrahydroquinolin-1-yl)propanoic acid ethyl ester
• 英文别名: ethyl 3-[5-[2-[2-(1,3-benzodioxol-5-yl)-5-methyl-1,3-oxazol-4-yl]ethoxy]-3,4-dihydro-2H-quinolin-1-yl]propanoate
• CAS: 479252-19-2
• 化学式: C₂₇H₃₀N₂O₆
• 分子量: 478.545
• InChiKey: ODLWTLAVPZVUPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient
  申请人：——

  公开号：US20040171835A1

  公开（公告）日：2004-09-02

  A compound of formula (I) 1 (wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a compound of formula (I) have an activity of regulating peroxisome proliferator activated receptor regulator, the compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or treatment agent for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

  化合物公式（I）1（其中所有符号均如规范中定义）及其盐，并且包括其作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于化合物公式（I）具有调节过氧化物酶体增殖物激活受体调节剂的活性，因此化合物公式（I）可用作降血糖剂、降血脂剂、预防和/或治疗代谢紊乱相关疾病（糖尿病、肥胖症、X综合症、高胆固醇血症、高脂蛋白血症等）、高脂血症、动脉硬化、高血压、循环系统疾病、暴饮暴食、冠心病等、提高高密度脂蛋白胆固醇的剂、降低低密度脂蛋白胆固醇和/或极低密度脂蛋白胆固醇的剂以及缓解糖尿病或X综合症风险因素的药物。
• TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1405848B1

  公开（公告）日：2008-05-07
• US6924295B2
  申请人：——

  公开号：US6924295B2

  公开（公告）日：2005-08-02