3-{4-[1-(4'-cyano-biphenyl-4-ylamino)-3-methyl-butyl]-benzoylamino}-propionic acid | 949119-06-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-{4-[1-(4'-cyano-biphenyl-4-ylamino)-3-methyl-butyl]-benzoylamino}-propionic acid
• 英文别名: 3-[[4-[1-[4-(4-Cyanophenyl)anilino]-3-methylbutyl]benzoyl]amino]propanoic acid
• CAS: 949119-06-6
• 化学式: C₂₈H₂₉N₃O₃
• 分子量: 455.557
• InChiKey: JLDJSIOVMRCTAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Glucagon Receptor Antagonists, Preparation and Therapeutic Uses
  申请人：Li Jianke

  公开号：US20080300308A1

  公开（公告）日：2008-12-04

  The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

  本发明揭示了一种具有葡萄糖素受体拮抗剂或逆拮抗剂活性的新型化合物I的，或其药学上可接受的盐，以及制备这些化合物的方法。在另一实施例中，该发明还揭示了包括化合物I的药物组合物，以及使用它们治疗糖尿病和其他与葡萄糖素相关的代谢紊乱等方法。
• GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1951661B1

  公开（公告）日：2012-08-08
• Methods For Treating Heart Failure Using Glucagon Receptor Antagonists
  申请人：REMD Biotherapeutics, Inc.

  公开号：US20170143673A1

  公开（公告）日：2017-05-25

  The present invention relates to methods for treating or preventing heart failure using a glucagon receptor antagonist or modulator. In various embodiments, the present invention relates to methods for treating post-myocardial infarction heart failure and lateral ventricular (LV) remodeling. In various embodiments, the present invention relates to methods for treating diabetic cardiomyopathy.
• US7696248B2
  申请人：——

  公开号：US7696248B2

  公开（公告）日：2010-04-13
• [EN] GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DU GLUCAGON, LEUR PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2007106181A2

  公开（公告）日：2007-09-20

  [EN] The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
  [FR] La présente invention concerne de nouveaux composés de formule I, ou leurs sels pharmaceutiquement acceptables, qui possèdent une activité d'antagoniste ou d'agoniste inverse des récepteurs du glucagon, ainsi que des procédés de préparation de ces composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant des composés de formule I, ainsi que des procédés les utilisant pour traiter des troubles diabétiques et d'autres troubles métaboliques liés au glucagon.