Benzyl 3-oxo-2-phenylnonanoate | 1048682-84-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl 3-oxo-2-phenylnonanoate
• CAS: 1048682-84-3
• 化学式: C₂₂H₂₆O₃
• 分子量: 338.447
• InChiKey: SGZDJWUUXOSGEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  庚醛 、 benzyl 2-diazo-2-phenylacetate 在 Al-loaded mesoporous silica MCM-41 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以41%的产率得到Benzyl 3-oxo-2-phenylnonanoate
  参考文献：
  名称：

  Selective synthesis of α-substituted β-keto esters from aldehydes and diazoesters on mesoporous silica catalysts

  摘要：

  The titled reactions are effectively catalyzed on mesoporous silica MCM-41 but not on amorphous silica prepared from the same starting materials as those of MCM-41. The ordered porous structure was essential to generate the acid catalysis. Planting of Al or Ti ion improved not only the catalytic activity but also the tolerance to basic functional groups of substrates. The catalytic activity of Al- or Ti-MCM-41 was better than that of SnCl2 and NbCl5 in the homogeneous phase. In particular, Al (or Ti)-MCM-41 was characteristically active for the reaction of aldehydes with a-substituted diazoesters to give 2-substituted-3-oxo propionic acid esters. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.077