| 628707-74-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• CAS: 628707-74-4
• 化学式: C₄₈H₄₆N₁₂O₈S₆
• 分子量: 1111.36
• InChiKey: VUZANUFSBHCXMR-MSMKCDNYSA-N

反应信息

• 作为反应物：
  描述：

  在 chromium (VI) oxide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

  摘要：

  Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC90=0.06 mug/mL) and vancomycin resistant Enterococcus spp. (VRE; MIC90=0.03 mug/mL); however its poor aqueous solubility has prohibited its development for the clinical treatment of infections. An integrated combinatorial and medicinal chemistry program was employed to identify derivatives of 1 that retain activity but possess greatly enhanced aqueous solubility. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00811-4
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

  摘要：

  Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC90=0.06 mug/mL) and vancomycin resistant Enterococcus spp. (VRE; MIC90=0.03 mug/mL); however its poor aqueous solubility has prohibited its development for the clinical treatment of infections. An integrated combinatorial and medicinal chemistry program was employed to identify derivatives of 1 that retain activity but possess greatly enhanced aqueous solubility. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00811-4