1-Brom-4-phenyl-pentan | 50334-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Brom-4-phenyl-pentan
• 英文别名: (5-Bromopentan-2-yl)benzene；5-bromopentan-2-ylbenzene
• CAS: 50334-08-2
• 化学式: C₁₁H₁₅Br
• 分子量: 227.144
• InChiKey: QPHBWKNXAHIYPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-Brom-4-phenyl-pentan 生成 8-Phenyl-nonansaeure
  参考文献：
  名称：

  Nenitzesco,C.D.; Glatz,A.M., Bulletin de la Societe Chimique de France, 1961, p. 218 - 222

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯基戊酸 在 lithium aluminium tetrahydride 、 三溴化磷 作用下， 生成 1-Brom-4-phenyl-pentan
  参考文献：
  名称：

  The Chemistry of Sultones. III. Formation of Six- in Preference to Five-Membered Ring Sultones¹

  摘要：

  DOI：

  10.1021/jo01058a038

文献信息

• Interaction inhibitors of tcf-4 with beta-catenin
  申请人：——

  公开号：US20040204477A1

  公开（公告）日：2004-10-14

  A compound of formula (I) is provided which is able to interact with &bgr;-catenin/TCF-4 binding site, having a structure essentially equivalent to a pharmacophore (IA), as herein described.

  提供了一种化合物，其化学式为(I)，能够与β-连环蛋白/TCF-4结合位点相互作用，其结构基本上等同于药效团(IA)，如本文所述。
• NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
  申请人：Flynn Bernard Luke

  公开号：US20100087430A1

  公开（公告）日：2010-04-08

  The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of K v 1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

  本发明涉及化合物，其在细胞中调节钾通道活性方面具有用处，特别是调节T细胞中发现的Kv1.3通道活性。本发明还涉及使用这些化合物治疗或预防自身免疫性和炎症性疾病，包括多发性硬化症，含有这些化合物的制药组合物以及它们的制备方法。
• WO2008/40057
  申请人：——

  公开号：——

  公开（公告）日：——
• Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors
  作者：Dennis M. Zimmerman、J. David Leander、Buddy E. Cantrell、Jon K. Reel、John Snoddy、Laurane G. Mendelsohn、Bryan G. Johnson、Charles H. Mitch

  DOI：10.1021/jm00072a001

  日期：1993.10

  A series of racemic N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines were evaluated for opioid agonist and antagonist activity at mu and kappa receptors. Several highly potent mu and kappa antagonists were discovered; however, no compounds with high selectivity for either the mu or kappa receptor were identified. Importantly, no derivative was found to have significant opioid agonist activity. Two derivatives were resolved, and the activities of the enantiomers were investigated. Only a limited stereochemical effect on opioid receptor selectivities was observed. The structure-activity relationships described establish the existence of an important lipophilic binding site distal to the nitrogen for both mu and kappa receptors and confirm the pure opioid antagonist pharmacophore nature of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine structure.
• The Chemistry of Sultones. I. Friedel-Crafts Reactions of Sultones^1a
  作者：William E. Truce、Fred D. Hoerger

  DOI：10.1021/ja01650a032

  日期：1954.11