5,6α-epoxy-3β-hydroxy-5α-cholan-24-oic acid methyl ester | 70214-25-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5,6α-epoxy-3β-hydroxy-5α-cholan-24-oic acid methyl ester
• 英文别名: 5,6α-Epoxy-3β-hydroxy-5α-cholan-24-saeure-methylester；Methyl-3beta-hydroxy-5alpha,6alpha-epoxycholanate；methyl (4R)-4-[(1S,2R,5S,7R,9S,11S,12S,15R,16R)-5-hydroxy-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-15-yl]pentanoate
• CAS: 70214-25-4
• 化学式: C₂₅H₄₀O₄
• 分子量: 404.59
• InChiKey: XTGSMFGCHJDFGH-DWCNNMIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5,6α-epoxy-3β-hydroxy-5α-cholan-24-oic acid methyl ester 在 氢氧化钾 作用下， 生成 5,6α-epoxy-3β-hydroxy-5α-cholan-24-oic acid
  参考文献：
  名称：

  Hattori, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1939, vol. 59, p. 32,40, 41; dtsch. Ref. S. 12

  摘要：

  DOI：
• 作为产物：
  描述：

  3B-羟基-D5-胆烯酸 在 过氧化氢苯甲酰 、 氯仿 、 硫酸 作用下， 生成 5,6α-epoxy-3β-hydroxy-5α-cholan-24-oic acid methyl ester
  参考文献：
  名称：

  Hattori, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1939, vol. 59, p. 32,40, 41; dtsch. Ref. S. 12

  摘要：

  DOI：

文献信息

• INHIBITION OF CHOROIDAL NEOVASCULARIZATION
  申请人：Apte Rajendra S.

  公开号：US20120301439A1

  公开（公告）日：2012-11-29

  Methods of treatment of diseases that include or are characterized by inappropriate or pathological neovascularization are disclosed. These diseases include diseases of the eye, such as diabetic retinopathy, retinopathy of prematurity, and choroidal neovascularization which can occur in age-related macular degeneration (AMD). Disclosed methods include administering agents that cause directly or indirectly upregulation of the ABCA1 transporter protein in macrophages. These agents include, without limitation, LXR agonists. In some embodiments, inhibitors of CETP expression or activity can also be effective. Administration routes can include, without limitation, intraocular, periocular, or systemic administration.
• US9121019B2
  申请人：——

  公开号：US9121019B2

  公开（公告）日：2015-09-01
• US9254285B2
  申请人：——

  公开号：US9254285B2

  公开（公告）日：2016-02-09
• US9399045B2
  申请人：——

  公开号：US9399045B2

  公开（公告）日：2016-07-26
• Hattori, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1939, vol. 59, p. 32,40, 41; dtsch. Ref. S. 12
  作者：Hattori

  DOI：——

  日期：——