4-[3-{4-[(2,4-dichlorobenzyl)oxy]benzyl}-7-fluoro-6-[2-fluoro-1-(fluoromethyl)ethoxy]-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde | 1162652-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[3-{4-[(2,4-dichlorobenzyl)oxy]benzyl}-7-fluoro-6-[2-fluoro-1-(fluoromethyl)ethoxy]-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde
• 英文别名: 4-[3-[[4-[(2,4-Dichlorophenyl)methoxy]phenyl]methyl]-6-(1,3-difluoropropan-2-yloxy)-7-fluoro-2,4-dioxoquinazolin-1-yl]piperidine-1-carbaldehyde
• CAS: 1162652-80-3
• 化学式: C₃₁H₂₈Cl₂F₃N₃O₅
• 分子量: 650.482
• InChiKey: JHUNWABRVNRMJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES
  申请人：Marciniak Gilbert

  公开号：US20120058987A1

  公开（公告）日：2012-03-08

  The subject matter of the present invention is the use of compounds of formula (I) in the form of a base, a hydrate or a solvate, or of mixtures thereof, as a medicament or for preparing a medicament intended for the treatment and/or prevention of disorders associated with the central nervous system (abbreviated to CNS) and/or associated with the peripheral nervous system (abbreviated to PNS).

  本发明的主题是将式（I）化合物以碱、水合物或溶剂合物的形式使用，或其混合物，作为药物或用于制备用于治疗和/或预防与中枢神经系统（缩写为CNS）相关的疾病和/或与外周神经系统（缩写为PNS）相关的疾病的药物。
• THERAPEUTIC APPLICATIONS IN THE CARDIOVASCULAR FIELD OF QUINAZOLINEDIONE DERIVATIVES
  申请人：JANIAK Philip

  公开号：US20120184522A1

  公开（公告）日：2012-07-19

  A subject-matter of the present invention is the use of compounds of formula (I) in the base, hydrate or solvate form or in the form of their mixtures, as medicaments or for the preparation of medicaments intended for the treatment of at least one cardiovascular disease and/or to prevent the appearance of at least one cardiovascular disease.

  本发明的主题是将式(I)化合物以其碱、水合物或溶剂合物形式或其混合物形式用作药物或用于制备用于治疗至少一种心血管疾病和/或预防至少一种心血管疾病的药物。
• QUINAZOLINEDIONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF
  申请人：CLAUSS Annie

  公开号：US20100298298A1

  公开（公告）日：2010-11-25

  The invention relates to quinazolinedione derivatives, processes for the preparation thereof and their therapeutic applications.

  本发明涉及喹唑啉二酮衍生物，其制备方法及其治疗应用。
• C-Met Modulators and Method of Use
  申请人：Bannen Lynne Canne

  公开号：US20120184523A1

  公开（公告）日：2012-07-19

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了一种用于调节蛋白激酶酶活性、调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学入侵）的化合物。更具体地，本发明提供了喹唑啉和喹啉，这些化合物抑制、调节和/或调节激酶受体，特别是c-Met、KDF、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导通路，以及包含这些化合物的组合物和使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供了制备上述化合物的方法和包含这些化合物的组合物。
• DÉRIVÉS DE QUINAZOLINEDIONE, LEUR PRÉPARATION ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：SANOFI

  公开号：EP2205593B1

  公开（公告）日：2016-01-13