4-氯萘-1-磺酰胺 | 6292-61-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-氯萘-1-磺酰胺
• 英文名称: 4-chloronaphthalene-1-sulfonamide
• 英文别名: 4-chloro-naphthalene-1-sulfonic acid amide；4-Chlor-naphthalin-1-sulfonsaeure-amid
• CAS: 6292-61-1
• 化学式: C₁₀H₈ClNO₂S
• mdl: MFCD01365830
• 分子量: 241.698
• InChiKey: YQXWHPSJAYLYED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氯萘-1-磺酰胺 在 potassium acetate 、 sodium carbonate 、 三苯基膦 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 0.5h， 生成 4-(6-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)naphthalene-1-sulfonamide trifluoroacetic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR INHIBITING BMP
  [FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE LA BMP

  摘要：

  本发明提供了BMP信号通路的小分子抑制剂，以及用于抑制BMP信号通路的组合物和方法。这些化合物和组合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或症状，包括炎症、心血管疾病、血液疾病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。这些化合物和组合物还可用于降低ApoB-100或LDL的循环水平，并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症；与脂质吸收或代谢缺陷相关的疾病、紊乱或综合征；或由高脂血症引起的疾病、紊乱或综合征。

  公开号：

  WO2016011019A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4-氯萘-1-磺酰胺
  参考文献：
  名称：

  Identification of Organic Compounds. I. Chlorosulfonic Acid as a Reagent for the Identification of Aryl Halides

  摘要：

  DOI：

  10.1021/ja01860a014

文献信息

• Compositions and Methods for Inhibiting BMP
  申请人：LEE Arthur

  公开号：US20170197968A1

  公开（公告）日：2017-07-13

  The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING BMP<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE LA BMP
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2016011019A1

  公开（公告）日：2016-01-21

  The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

  本发明提供了BMP信号通路的小分子抑制剂，以及用于抑制BMP信号通路的组合物和方法。这些化合物和组合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或症状，包括炎症、心血管疾病、血液疾病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。这些化合物和组合物还可用于降低ApoB-100或LDL的循环水平，并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症；与脂质吸收或代谢缺陷相关的疾病、紊乱或综合征；或由高脂血症引起的疾病、紊乱或综合征。
• Identification of Organic Compounds. I. Chlorosulfonic Acid as a Reagent for the Identification of Aryl Halides
  作者：Ernest H. Huntress、Frederick H. Carten

  DOI：10.1021/ja01860a014

  日期：1940.3