(S)-N-(5-((R)-2-(2-(difluoromethyl)-5-fluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide | 1223403-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-N-(5-((R)-2-(2-(difluoromethyl)-5-fluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
• 英文别名: (3S)-N-[5-[(2R)-2-[2-(difluoromethyl)-5-fluorophenyl]pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
• CAS: 1223403-90-4
• 化学式: C₂₂H₂₃F₃N₆O₂
• 分子量: 460.459
• InChiKey: GMWUABQJDWHYLA-KBXCAEBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  86
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS<br/>[FR] COMPOSÉS DE PYRAZOLO[1,5-A]PYRIMIDINE SUBSTITUÉS COMME INHIBITEURS DE LA TRK KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010048314A1

  公开（公告）日：2010-04-29

  Compounds of Formula (I) in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.

  式（I）中R1、R2、R3、R4、X、Y和n的化合物具有规范中给定的含义，是Trk激酶的抑制剂，并且在治疗可以用Trk激酶抑制剂治疗的疾病中是有用的。
• Substituted Pyrazolo[1,5-a]Pyrimidine Compounds as TRK Kinase Inhibitors
  申请人：Haas Julia

  公开号：US20110195948A1

  公开（公告）日：2011-08-11

  Compounds of Formula (I) in which R 1 , R 2 , R 3 , R 4 , X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.

  式(I)的化合物中，其中R1、R2、R3、R4、X、Y和n的含义如规范中所述，是Trk激酶的抑制剂，可用于治疗可用Trk激酶抑制剂治疗的疾病。
• METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS
  申请人：Array BioPharma Inc.

  公开号：US20150005499A1

  公开（公告）日：2015-01-01

  Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

  在哺乳动物中，用于合成用于治疗疼痛、癌症、炎症、神经退行性疾病或克鲁茨氏锥虫感染的化合物。
• METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS
  申请人：Array BioPharma Inc.

  公开号：US20150133429A1

  公开（公告）日：2015-05-14

  Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

  在哺乳动物中，用于合成用于治疗疼痛、癌症、炎症、神经退行性疾病或克鲁茨菌感染的化合物的化合物。
• METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS
  申请人：Array BioPharma, Inc.

  公开号：US20160228441A1

  公开（公告）日：2016-08-11

  Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

  用于合成用于治疗哺乳动物疼痛，癌症，炎症，神经退行性疾病或克鲁茨菌感染的化合物。