1-t-Butyl-5-methyl-hydantoin | 54508-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-t-Butyl-5-methyl-hydantoin
• 英文别名: 1-Tert-butyl-5-methylimidazolidine-2,4-dione
• CAS: 54508-45-1
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: YFJNRIWKPJXIQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• MATRIX METALLOPROTEINASE INHIBITORS
  申请人：RANBAXY LABORATORIES LIMITED

  公开号：US20140148459A1

  公开（公告）日：2014-05-29

  This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and pounds.

  这项发明还涉及含有本发明化合物的药物组合物，以及治疗哮喘、类风湿关节炎、慢性阻塞性肺病、鼻炎、骨关节炎、银屑病性关节炎、牛皮癣、肺纤维化、肺部炎症、急性呼吸窘迫综合征、牙周炎、多发性硬化症、牙龈炎、牙龈炎、动脉粥样硬化、干眼症、新生内膜增生导致再狭窄和缺血性心力衰竭、中风、肾脏疾病、肿瘤转移和磅的方法。
• Hydantoin containing deoxyuridine triphosphatase inhibitors
  申请人：CV6 Therapeutics (NI) Limited

  公开号：US10858344B2

  公开（公告）日：2020-12-08

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

  本文提供了 dUTP 酶抑制剂、包含此类化合物的组合物以及使用此类化合物和组合物的方法。
• HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
  申请人：CV6 Therapeutics (NI) Limited

  公开号：US20180186737A1

  公开（公告）日：2018-07-05

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
• DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE
  申请人：University of Southern California

  公开号：US20180194740A1

  公开（公告）日：2018-07-12

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.
• DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING CYCLOPROPANO LINKAGE
  申请人：CV6 Therapeutics (NI) Limited

  公开号：US20180201586A1

  公开（公告）日：2018-07-19

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.