(3aR,7R,7aR)-7-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3a-methyl-6-oxo-4,5,7,7a-tetrahydro-3H-indene-1-carbaldehyde | 1228108-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3aR,7R,7aR)-7-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3a-methyl-6-oxo-4,5,7,7a-tetrahydro-3H-indene-1-carbaldehyde
• CAS: 1228108-53-9
• 化学式: C₁₈H₂₅NO₄
• 分子量: 319.401
• InChiKey: GDPWFGJKDKEHCO-SCNOPHJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 三丁基膦 作用下， 以 乙腈 为溶剂， 生成 (3aR,7R,7aR)-7-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-3a-methyl-6-oxo-4,5,7,7a-tetrahydro-3H-indene-1-carbaldehyde 、
  参考文献：
  名称：

  Enantioselective synthesis of bicarbocyclic structures with an all-carbon quaternary stereocenter through sequential cross metathesis and intramolecular Rauhut–Currier reaction

  摘要：

  A new extension of the Birch-Cope sequence is described which allows the efficient enantioselective construction of highly functionalized, fused bicarbocyclic structures with an all-carbon quaternary stereo-center in two steps. The two-step sequence includes a cross metathesis between a terminal alkene and a polarized alkene followed by an intramolecular Rauhut-Currier reaction with a trialkylphosphine catalyst. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.026