5-[(Decylamino)-[4-[[4-[[4-[(decylamino)-(3,3,8,8-tetramethyl-2,7-dioxo-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonan-5-yl)methyl]phenoxy]methyl]phenyl]methoxy]phenyl]methyl]-3,3,8,8-tetramethyl-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonane-2,7-dione | 470685-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[(Decylamino)-[4-[[4-[[4-[(decylamino)-(3,3,8,8-tetramethyl-2,7-dioxo-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonan-5-yl)methyl]phenoxy]methyl]phenyl]methoxy]phenyl]methyl]-3,3,8,8-tetramethyl-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonane-2,7-dione
• 英文别名: 5-[(decylamino)-[4-[[4-[[4-[(decylamino)-(3,3,8,8-tetramethyl-2,7-dioxo-1,4,6,9-tetraoxa-5λ5-phosphaspiro[4.4]nonan-5-yl)methyl]phenoxy]methyl]phenyl]methoxy]phenyl]methyl]-3,3,8,8-tetramethyl-1,4,6,9-tetraoxa-5λ5-phosphaspiro[4.4]nonane-2,7-dione
• CAS: 470685-94-0
• 化学式: C₅₈H₈₆N₂O₁₄P₂
• 分子量: 1097.27
• InChiKey: YALDNBUCJHHBBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  76
• 可旋转键数：
  30
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  185
• 氢给体数：
  2
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  5-[(Decylamino)-[4-[[4-[[4-[(decylamino)-(3,3,8,8-tetramethyl-2,7-dioxo-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonan-5-yl)methyl]phenoxy]methyl]phenyl]methoxy]phenyl]methyl]-3,3,8,8-tetramethyl-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonane-2,7-dione 在 盐酸 、 乙腈 作用下， 以 水 为溶剂， 反应 6.0h， 生成 N-decyl-[α-amino(p-hydroxybenzyl)]phosphonic acid
  参考文献：
  名称：

  Efficient synthesis of bolaform- and gemini-type alkyl-bis-[(α-amino)phosphonocarboxylic or phosphonic acid] surfactants

  摘要：

  The synthesis of a new series of bolaform- and gemini-type phosphorus acid surfactants is described. The Pudovik addition reaction of P-H bond tetraoxyspirophosphoranes to symmetrical, prochiral bis-imines bearing different more or less long and rigid linkers occurs instantaneously at room temperature. This reaction is diastereoselective and quantitatively leads to the corresponding alkyl-bis-[alpha-aminospirophosphoranes] in good to high diastereomeric ratio. Selective and one-pot hydrolysis of these P*-C* bond bis-spirophosphoranes can be readily achieved either at room temperature by moist solvents giving the corresponding alkyl-bis-[alpha-aminophosphonocarboxylic acid] amphiphiles, or by a more drastic reaction of 20% aqueous hydrochloric acid under reflux affording free alkyl-bis[alpha-aminophosphonic acid] surfactants in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00535-5
• 作为产物：
  描述：

  1,4-benzyloxy-bis(4-benzaldehyde) 在 3 A molecular sieve 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 6.0h， 生成 5-[(Decylamino)-[4-[[4-[[4-[(decylamino)-(3,3,8,8-tetramethyl-2,7-dioxo-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonan-5-yl)methyl]phenoxy]methyl]phenyl]methoxy]phenyl]methyl]-3,3,8,8-tetramethyl-1,4,6,9-tetraoxa-5lambda5-phosphaspiro[4.4]nonane-2,7-dione
  参考文献：
  名称：

  Efficient synthesis of bolaform- and gemini-type alkyl-bis-[(α-amino)phosphonocarboxylic or phosphonic acid] surfactants

  摘要：

  The synthesis of a new series of bolaform- and gemini-type phosphorus acid surfactants is described. The Pudovik addition reaction of P-H bond tetraoxyspirophosphoranes to symmetrical, prochiral bis-imines bearing different more or less long and rigid linkers occurs instantaneously at room temperature. This reaction is diastereoselective and quantitatively leads to the corresponding alkyl-bis-[alpha-aminospirophosphoranes] in good to high diastereomeric ratio. Selective and one-pot hydrolysis of these P*-C* bond bis-spirophosphoranes can be readily achieved either at room temperature by moist solvents giving the corresponding alkyl-bis-[alpha-aminophosphonocarboxylic acid] amphiphiles, or by a more drastic reaction of 20% aqueous hydrochloric acid under reflux affording free alkyl-bis[alpha-aminophosphonic acid] surfactants in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00535-5