| 1291080-95-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1291080-95-9
• 化学式: C₂₈H₂₉NO₄
• 分子量: 443.543
• InChiKey: BJZDBJYNKJNAPZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以47%的产率得到
  参考文献：
  名称：

  Selective Activation of Enantiotopic C(sp³)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

  摘要：

  Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).

  DOI：

  10.1021/ja2014955

文献信息

• Catalytic Enantioselective tert-Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5-Hydrogen Transfer
  作者：Liujuan Chen、Long Zhang、Jian Lv、Jin-Pei Cheng、Sanzhong Luo

  DOI：10.1002/chem.201201532

  日期：2012.7.16

  Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5‐H transfer specifically and stereoselectively in tert‐aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).

  通过ABC进行的选择性H转移：开发了一种新型的不对称二元酸催化剂，可在叔氨基环化反应中特异性和立体选择性地促进1,5-H转移，具有出色的活性，高对映选择性和广泛的底物范围。事实证明，H原子（红色）通过立体特异性表面途径转移（参见方案）。