9-pyrrolidin-2-yl-9H-fluoren-9-ol | 1039340-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-pyrrolidin-2-yl-9H-fluoren-9-ol
• 英文别名: 9-Pyrrolidin-2-ylfluoren-9-ol
• CAS: 1039340-42-5
• 化学式: C₁₇H₁₇NO
• 分子量: 251.328
• InChiKey: AFJCYLOZOIEWCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 samarium diiodide 作用下， 以 四氢呋喃 、 水 为溶剂， 以90 mg的产率得到9-pyrrolidin-2-yl-9H-fluoren-9-ol
  参考文献：
  名称：

  A Direct and Versatile Access to α,α-Disubstituted 2-Pyrrolidinylmethanols by SmI₂-Mediated Reductive Coupling

  摘要：

  Various alpha,alpha-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a Sml(2)-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-alpha,alpha-diphenylprolinol is also easily prepared and resolved.

  DOI：

  10.1021/ol800982n

文献信息

• [EN] TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION<br/>[FR] TECHNOLOGIES UTILES POUR LA PRÉPARATION D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2020191252A1

  公开（公告）日：2020-09-24

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

  除其他事项外，本公开提供了寡核苷酸制备技术，特别是手性控制的寡核苷酸制备技术，这些技术大大提高了粗品纯度和产量，并显著降低了制造成本。
• TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION
  申请人：BOWMAN Keith Andrew

  公开号：US20200231620A1

  公开（公告）日：2020-07-23

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
• [EN] TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION<br/>[FR] TECHNOLOGIES DE PRÉPARATION D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2019055951A1

  公开（公告）日：2019-03-21

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.