4-Chloro-2-[5-(5-chloro-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol | 2491-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Chloro-2-[5-(5-chloro-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol
• CAS: 2491-98-7
• 化学式: C₁₄H₈Cl₂N₂O₃
• 分子量: 323.135
• InChiKey: NPTKCEIYFKHSCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氯代水杨酸 、 5-氯-2-羟基苯甲酰肼 在 nickel(III) oxide 、 三氯氧磷 作用下， 以86%的产率得到4-Chloro-2-[5-(5-chloro-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol
  参考文献：
  名称：

  Catalytic Application of Electrochemically Prepared Nickel Oxide Nanoparticles to Synthesize 2, 5–Disubstituted-1, 3, 4–Oxadiazoles

  摘要：

  The present work aims to synthesize 2,5-disubstituted-1,3,4-oxadiazoles using electrochemically prepared nanoparticles of nickel oxide as catalyst. The nanoparticles thus prepared using electrochemical syntheses are in appreciable yield. The tetrabutyl phosphonium bromide has been used for capping followed by UV, FTIR, XRD, SEM EDS and TEM SAED studies for the characterization. The 2,5-disubstituted-1,3,4-oxadiazoles were synthesized from substituted benzoic acids and their hydrazides in microwave synthesis system using prepared nanoparticles as a catalyst.

  DOI：

  10.13005/ojc/360213