iodo-phenyl-acetic acid amide | 121800-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: iodo-phenyl-acetic acid amide
• 英文别名: Jod-phenyl-essigsaeure-amid；2-Iodo-2-phenylacetamide
• CAS: 121800-20-2
• 化学式: C₈H₈INO
• 分子量: 261.062
• InChiKey: YEZLCPTYWMYTRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyl-N-(pyrimidin-2-yl)benzenesulfonamide 、 iodo-phenyl-acetic acid amide 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.67h， 以80%的产率得到2-[2-(4-Methylphenyl)sulfonyliminopyrimidin-1-yl]-2-phenylacetamide
  参考文献：
  名称：

  2-磺酰亚氨基二氢嘧啶：一类新型镇痛化合物

  摘要：

  已经合成了一系列 2-磺酰亚氨基二氢嘧啶衍生物，并在体内评估了它们的镇痛和抗炎活性。将结果与乙酰水杨酸的结果进行比较。化合物 6Ab-d 和 6Be 在醋酸诱导的腹部收缩试验中显示出有趣的镇痛特性。根据角叉菜胶-后爪水肿试验的结果，化合物 6Af 显示出潜在的抗炎活性。

  DOI：

  10.1002/ardp.200800107
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 alkaline aqueous potassium hypoiodite solution 作用下， 生成 iodo-phenyl-acetic acid amide
  参考文献：
  名称：

  Increased blood ammonia in hypoxia during exercise in humans

  摘要：

  The effect of acute hypoxia on blood concentration of ammonia ([NH3](b)) and lactate ([la(-)](b)) was studied during incremental exercise(IE), and two-step constant workload exercises (CE). Fourteen endurance-trained subjects performed incremental exercise on a cycle ergometer under normoxic (21% O-2) and hypoxic (10.4% O-2) conditions. Eight endurance-trained subjects performed two-step constant workload exercise at sea level and at a simulated altitude of 5000 m (hypobaric chamber, P-B=405 Torr; P-o2=85 Torr) in random order. In normoxia, the first step lasted 25 minutes at an intensity of 85 % of the individual ventilatory anaerobic threshold (AT(vent), (ind)) at sea level. This reduced workload was followed by a second step of 5 minutes at 115% of their AT(vent, ind). This test was repeated into a hypobaric chamber, at a simulated altitude of 5,000 m. The first step in hypoxia was at an intensity of 65 % of AT(vent, ind.), whereas workload for the second step at simulated altitude was the same as that of the first workload in normoxia (85 % of AT(vent, ind)). During IE, [NH3](b) and [la(-)](b) were significantly higher in hypoxia than in normoxia. Increases in these metabolites were highly correlated in each condition. The onset of [NH3](b) and [la(-)](b) accumulation occurred at different exercise intensity in normoxia (181W for lactate and 222W for ammonia) and hypoxia (100W for lactate and 140W for ammonia). In both conditions, during CE, [NH3](b) showed a significant increase during each of the two steps, whereas [la(-)](b) increased to a steady-state in the initial step, followed by a sharp increase above 4 mM.L-1 during the second. Although exercise intensity was much lower in hypoxia than in normoxia, [NH3](b) was always higher at simulated altitude. Thus, for the same workload, [NH3](b) in hypoxia was significantly higher (p<0.05) than in normoxia. Our data suggest that there is a close relationship between [NH3](b) and [la(-)](b) in normoxia and hypoxia during graded intensity exercises. The accumulation of ammonia in blood is independent of that of lactate during constant intense exercise. Hypoxia increases the concentration of ammonia in blood during exercise.

  DOI：

  10.1007/bf03179824

文献信息

• COMPOSITIONS AND METHODS FOR DETECTION OF PROTEIN S-NITROSYLATION AND OXIDATION
  申请人：Academia Sinica

  公开号：EP2982697A1

  公开（公告）日：2016-02-10

  The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.

  本发明公开了一种新型分离抗体，它能与 N-苯基乙酰胺基团特异性结合。本发明还公开了相关的组合物、试剂盒、体内或体外检测蛋白质 S-亚硝基化或氧化的方法以及药物筛选方法。
• Compositions and methods for detection of protein S-nitrosylation and oxidation
  申请人：ACADEMIA SINICA

  公开号：US10072097B2

  公开（公告）日：2018-09-11

  The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.

  本发明公开了一种新型分离抗体，它能与 N-苯基乙酰胺基团特异性结合。本发明还公开了相关的组合物、试剂盒、体内或体外检测蛋白质 S-亚硝基化或氧化的方法以及药物筛选方法。
• POLYPEPTIDE-DENDRIMER COMPLEXES
  申请人：DADE INTERNATIONAL INC.

  公开号：EP0786087A1

  公开（公告）日：1997-07-30
• PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES
  申请人：Bristol-Myers Squibb Company

  公开号：EP2685982B1

  公开（公告）日：2017-07-05
• US6083708A
  申请人：——

  公开号：US6083708A

  公开（公告）日：2000-07-04